Wolfgang Uter1, Johannes Geier, Peter Frosch, Axel Schnuch. 1. Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, Erlangen, Germany. wolfgang.uter@imbe.med.uni-erlangen.de
Abstract
BACKGROUND: Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. OBJECTIVES: To examine the current frequency of contact sensitization to fragrance allergens in patients routinely patch tested for suspected allergic contact dermatitis with the baseline series and special series. PATIENTS AND METHODS: Between 2005 and 2008, 40 709 patients were patch tested in the departments of the Information Network of Departments of Dermatology (http://www.ivdk.org). Results with selected fragrances were analysed. RESULTS: Of all patients tested with the German baseline series, 15.1% reacted positively to fragrance mix (FM) I (6.6% positive), FM II (4.6% positive) or Myroxylon pereirae resin (balsam of Peru, 6.8% positive). Among the single constituents of FM I, Evernia prunastri [oak moss absolute (abs.)] was the leading allergen, and amyl cinnamal the least frequent allergen. Among fragrances not included in FM I or FM II, Evernia furfuracea (tree moss abs.) was the most common allergen. CONCLUSIONS: For diagnostic purposes, it is necessary to combine several screening agents. The frequency of contact sensitization differs greatly between single fragrances.
BACKGROUND: Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. OBJECTIVES: To examine the current frequency of contact sensitization to fragrance allergens in patients routinely patch tested for suspected allergic contact dermatitis with the baseline series and special series. PATIENTS AND METHODS: Between 2005 and 2008, 40 709 patients were patch tested in the departments of the Information Network of Departments of Dermatology (http://www.ivdk.org). Results with selected fragrances were analysed. RESULTS: Of all patients tested with the German baseline series, 15.1% reacted positively to fragrance mix (FM) I (6.6% positive), FM II (4.6% positive) or Myroxylon pereirae resin (balsam of Peru, 6.8% positive). Among the single constituents of FM I, Evernia prunastri [oak moss absolute (abs.)] was the leading allergen, and amyl cinnamal the least frequent allergen. Among fragrances not included in FM I or FM II, Evernia furfuracea (tree moss abs.) was the most common allergen. CONCLUSIONS: For diagnostic purposes, it is necessary to combine several screening agents. The frequency of contact sensitization differs greatly between single fragrances.
Authors: Candice Johnson; Lennart T Anger; Romualdo Benigni; David Bower; Frank Bringezu; Kevin M Crofton; Mark T D Cronin; Kevin P Cross; Magdalena Dettwiler; Markus Frericks; Fjodor Melnikov; Scott Miller; David W Roberts; Diana Suarez-Rodriguez; Alessandra Roncaglioni; Elena Lo Piparo; Raymond R Tice; Craig Zwickl; Glenn J Myatt Journal: Comput Toxicol Date: 2021-11-08
Authors: Mihwa Na; Devin O'Brien; Maura Lavelle; Isabelle Lee; G Frank Gerberick; Anne Marie Api Journal: Dermatitis Date: 2022 Mar-Apr 01 Impact factor: 4.867