BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
Authors: Cari M Kitahara; Marjorie L McCullough; Silvia Franceschi; Sabina Rinaldi; Alicja Wolk; Gila Neta; Hans Olov Adami; Kristin Anderson; Gabriella Andreotti; Laura E Beane Freeman; Leslie Bernstein; Julie E Buring; Francoise Clavel-Chapelon; Lisa A De Roo; Yu-Tang Gao; J Michael Gaziano; Graham G Giles; Niclas Håkansson; Pamela L Horn-Ross; Vicki A Kirsh; Martha S Linet; Robert J MacInnis; Nicola Orsini; Yikyung Park; Alpa V Patel; Mark P Purdue; Elio Riboli; Kimberly Robien; Thomas Rohan; Dale P Sandler; Catherine Schairer; Arthur B Schneider; Howard D Sesso; Xiao-Ou Shu; Pramil N Singh; Piet A van den Brandt; Elizabeth Ward; Elisabete Weiderpass; Emily White; Yong-Bing Xiang; Anne Zeleniuch-Jacquotte; Wei Zheng; Patricia Hartge; Amy Berrington de González Journal: Thyroid Date: 2016-02 Impact factor: 6.568
Authors: Cari M Kitahara; Sophia S Wang; Beatrice S Melin; Zhaoming Wang; Melissa Braganza; Peter D Inskip; Demetrius Albanes; Ulrika Andersson; Laura E Beane Freeman; Julie E Buring; Tania Carreón; Maria Feychting; Susan M Gapstur; J Michael Gaziano; Graham G Giles; Goran Hallmans; Susan E Hankinson; Roger Henriksson; Ann W Hsing; Christoffer Johansen; Martha S Linet; Roberta McKean-Cowdin; Dominique S Michaud; Ulrike Peters; Mark P Purdue; Nathaniel Rothman; Avima M Ruder; Howard D Sesso; Gianluca Severi; Xiao-Ou Shu; Victoria L Stevens; Kala Visvanathan; Martha A Waters; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Wei Zheng; Robert Hoover; Joseph F Fraumeni; Nilanjan Chatterjee; Meredith Yeager; Stephen J Chanock; Patricia Hartge; Preetha Rajaraman Journal: Int J Epidemiol Date: 2012-08 Impact factor: 7.196
Authors: Cari M Kitahara; Michael Gamborg; Preetha Rajaraman; Thorkild I A Sørensen; Jennifer L Baker Journal: Am J Epidemiol Date: 2014-09-09 Impact factor: 4.897
Authors: S Rinaldi; C Biessy; M Hernandez; F Lesueur; I dos-Santos-Silva; M S Rice; M Lajous; R Lopez-Ridaura; G Torres-Mejía; I Romieu Journal: Int J Cancer Date: 2013-10-05 Impact factor: 7.396
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