Literature DB >> 20730557

Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine.

Shanta Raj Bhattarai1, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L Castañeda, Stephanie L Brock, David Oupicky.   

Abstract

PURPOSE: To prepare mesoporous silica-based delivery systems capable of simultaneous delivery of drugs and nucleic acids.
METHODS: The surface of mesoporous silica nanoparticles (MSN) was modified with poly(ethylene glycol) (PEG) and poly(2-(dimethylamino)ethylmethacrylate) (PDMAEMA) or poly(2-(diethylamino)ethylmethacrylate) (PDEAEMA). The particles were then loaded with a lysosomotropic agent chloroquine (CQ) and complexed with plasmid DNA or siRNA. The ability of the synthesized particles to deliver combinations of CQ and nucleic acids was evaluated using luciferase plasmid DNA and siRNA targeting luciferase and GAPDH.
RESULTS: The results show a slow partial MSN dissolution to form hollow silica nanoparticles in aqueous solution. The biological studies show that polycation-modified MSN are able to simultaneously deliver CQ with DNA and siRNA. The co-delivery of CQ and the nucleic acids leads to a significantly increased transfection and silencing activity of the complexes compared with MSN not loaded with CQ.
CONCLUSION: PEGylated MSN modified with polycations are promising delivery vectors for combination drug/nucleic acid therapies.

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Year:  2010        PMID： 20730557      PMCID： PMC4108588          DOI： 10.1007/s11095-010-0245-0

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  27 in total

1.  A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent.

Authors:  Daniela R Radu; Cheng-Yu Lai; Ksenija Jeftinija; Eric W Rowe; Srdija Jeftinija; Victor S-Y Lin
Journal:  J Am Chem Soc       Date:  2004-10-20       Impact factor: 15.419

2.  Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity.

Authors:  Yu-Shen Lin; Christy L Haynes
Journal:  J Am Chem Soc       Date:  2010-04-07       Impact factor: 15.419

3.  Fine-tuning the degree of organic functionalization of mesoporous silica nanosphere materials via an interfacially designed co-condensation method.

Authors:  Daniela R Radu; Cheng-Yu Lai; Jianguo Huang; Xu Shu; Victor S-Y Lin
Journal:  Chem Commun (Camb)       Date:  2004-12-20       Impact factor: 6.222

4.  A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.

Authors:  Cheng-Yu Lai; Brian G Trewyn; Dusan M Jeftinija; Ksenija Jeftinija; Shu Xu; Srdija Jeftinija; Victor S-Y Lin
Journal:  J Am Chem Soc       Date:  2003-04-16       Impact factor: 15.419

5.  Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery.

Authors:  Jianjun Cheng; Ryan Zeidan; Swaroop Mishra; Aijie Liu; Suzie H Pun; Rajan P Kulkarni; Gregory S Jensen; Nathalie C Bellocq; Mark E Davis
Journal:  J Med Chem       Date:  2006-11-02       Impact factor: 7.446

6.  Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.

Authors:  D Oupický; R C Carlisle; L W Seymour
Journal:  Gene Ther       Date:  2001-05       Impact factor: 5.250

7.  A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity.

Authors:  D Fischer; T Bieber; Y Li; H P Elsässer; T Kissel
Journal:  Pharm Res       Date:  1999-08       Impact factor: 4.200

8.  Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.

Authors:  N Malik; R Wiwattanapatapee; R Klopsch; K Lorenz; H Frey; J W Weener; E W Meijer; W Paulus; R Duncan
Journal:  J Control Release       Date:  2000-03-01       Impact factor: 9.776

9.  Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 status.

Authors:  Sven R Quist; Shan Wang-Gohrke; Tanja Köhler; Rolf Kreienberg; Ingo B Runnebaum
Journal:  Cancer Gene Ther       Date:  2004-08       Impact factor: 5.987

10.  In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.

Authors:  Dagmar Fischer; Youxin Li; Barbara Ahlemeyer; Josef Krieglstein; Thomas Kissel
Journal:  Biomaterials       Date:  2003-03       Impact factor: 12.479
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  24 in total

1.  Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells.

Authors:  Ying Xie; Fei Yu; Weimin Tang; Bolutito Oluwole Alade; Zheng-Hong Peng; Yazhe Wang; Jing Li; David Oupický
Journal:  Macromol Biosci       Date:  2017-08-04       Impact factor: 4.979

2.  Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Authors:  Carlee E Ashley; Eric C Carnes; Katharine E Epler; David P Padilla; Genevieve K Phillips; Robert E Castillo; Dan C Wilkinson; Brian S Wilkinson; Cameron A Burgard; Robin M Kalinich; Jason L Townson; Bryce Chackerian; Cheryl L Willman; David S Peabody; Walker Wharton; C Jeffrey Brinker
Journal:  ACS Nano       Date:  2012-02-14       Impact factor: 15.881

Review 3.  Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy.

Authors:  Anish Babu; Ranganayaki Muralidharan; Narsireddy Amreddy; Meghna Mehta; Anupama Munshi; Rajagopal Ramesh
Journal:  IEEE Trans Nanobioscience       Date:  2016-12       Impact factor: 2.935

Review 4.  Recent advances in delivery of drug-nucleic acid combinations for cancer treatment.

Authors:  Jing Li; Yan Wang; Yu Zhu; David Oupický
Journal:  J Control Release       Date:  2013-04-25       Impact factor: 9.776

5.  Surface functionalization of mesoporous silica nanoparticles controls loading and release behavior of mitoxantrone.

Authors:  Amit Wani; Elayaraja Muthuswamy; Galbokka H Layan Savithra; Guangzhao Mao; Stephanie Brock; David Oupický
Journal:  Pharm Res       Date:  2012-05-04       Impact factor: 4.200

6.  Recent advances in nonviral vectors for gene delivery.

Authors:  Xia Guo; Leaf Huang
Journal:  Acc Chem Res       Date:  2011-08-26       Impact factor: 22.384

Review 7.  Progress and perspective of inorganic nanoparticle-based siRNA delivery systems.

Authors:  Ying Jiang; Shuaidong Huo; Joseph Hardie; Xing-Jie Liang; Vincent M Rotello
Journal:  Expert Opin Drug Deliv       Date:  2016-01-14       Impact factor: 6.648

Review 8.  Ligand-targeted theranostic nanomedicines against cancer.

Authors:  Virginia J Yao; Sara D'Angelo; Kimberly S Butler; Christophe Theron; Tracey L Smith; Serena Marchiò; Juri G Gelovani; Richard L Sidman; Andrey S Dobroff; C Jeffrey Brinker; Andrew R M Bradbury; Wadih Arap; Renata Pasqualini
Journal:  J Control Release       Date:  2016-01-06       Impact factor: 9.776

9.  Fabrication of multiresponsive bioactive nanocapsules through orthogonal self-assembly.

Authors:  Yi-Cheun Yeh; Rui Tang; Rubul Mout; Youngdo Jeong; Vincent M Rotello
Journal:  Angew Chem Int Ed Engl       Date:  2014-04-01       Impact factor: 15.336

10.  Multifunctional hierarchically assembled nanostructures as complex stage-wise dual-delivery systems for coincidental yet differential trafficking of siRNA and paclitaxel.

Authors:  Mahmoud Elsabahy; Ritu Shrestha; Corrie Clark; Sara Taylor; Jeffrey Leonard; Karen L Wooley
Journal:  Nano Lett       Date:  2013-04-10       Impact factor: 11.189
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