Literature DB >> 15479063

A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent.

Daniela R Radu1, Cheng-Yu Lai, Ksenija Jeftinija, Eric W Rowe, Srdija Jeftinija, Victor S-Y Lin.   

Abstract

We synthesized a MCM-41-type mesoporous silica nanosphere (MSN)-based gene transfection system, where second generation (G2) polyamidoamines (PAMAMs) were covalently attached to the surface of MSN. The G2-PAMAM-capped MSN material (G2-MSN) was used to complex with a plasmid DNA (pEGFP-C1) that encodes for an enhanced green fluorescence protein. The gene transfection efficacy, uptake mechanism, and biocompatibility of the G2-MSN system with various cell types, such as neural glia (astrocytes), human cervical cancer (HeLa), and Chinese hamster ovarian (CHO) cells, were investigated. The mesoporous structure of the MSN material allows membrane-impermeable molecules, such as pharmaceutical drugs and fluorescent dyes, to be encapsulated inside the MSN channels. The system renders the possibility to serve as a universal transmembrane carrier for intracellular drug delivery and imaging applications.

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Year:  2004        PMID： 15479063     DOI： 10.1021/ja046275m

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  82 in total

1.  Stimulus-responsive controlled release system by covalent immobilization of an enzyme into mesoporous silica nanoparticles.

Authors:  Jessica Méndez; Alina Monteagudo; Kai Griebenow
Journal:  Bioconjug Chem       Date:  2012-03-13       Impact factor: 4.774

2.  Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine.

Authors:  Shanta Raj Bhattarai; Elayaraja Muthuswamy; Amit Wani; Michal Brichacek; Antonio L Castañeda; Stephanie L Brock; David Oupicky
Journal:  Pharm Res       Date:  2010-08-21       Impact factor: 4.200

Review 3.  Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations.

Authors:  Wassana Wijagkanalan; Shigeru Kawakami; Mitsuru Hashida
Journal:  Pharm Res       Date:  2010-12-23       Impact factor: 4.200

Review 4.  Surface functionalization of nanoparticles for nanomedicine.

Authors:  Rubul Mout; Daniel F Moyano; Subinoy Rana; Vincent M Rotello
Journal:  Chem Soc Rev       Date:  2012-02-06       Impact factor: 54.564

5.  Nanoscale control of silica particle formation via silk-silica fusion proteins for bone regeneration.

Authors:  Aneta J Mieszawska; Lauren D Nadkarni; Carole C Perry; David L Kaplan
Journal:  Chem Mater       Date:  2010-10-26       Impact factor: 9.811

6.  The biocompatibility of mesoporous silicates.

Authors:  Sarah P Hudson; Robert F Padera; Robert Langer; Daniel S Kohane
Journal:  Biomaterials       Date:  2008-10       Impact factor: 12.479

Review 7.  Hybrid nanoparticles for detection and treatment of cancer.

Authors:  Michael J Sailor; Ji-Ho Park
Journal:  Adv Mater       Date:  2012-05-21       Impact factor: 30.849

Review 8.  Handling of iron oxide and silver nanoparticles by astrocytes.

Authors:  Michaela C Hohnholt; Mark Geppert; Eva M Luther; Charlotte Petters; Felix Bulcke; Ralf Dringen
Journal:  Neurochem Res       Date:  2012-12-06       Impact factor: 3.996

9.  Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.

Authors:  Alex M Chen; Min Zhang; Dongguang Wei; Dirk Stueber; Oleh Taratula; Tamara Minko; Huixin He
Journal:  Small       Date:  2009-12       Impact factor: 13.281

10.  Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery.

Authors:  Yaroslav Klichko; Monty Liong; Eunshil Choi; Sarah Angelos; Andre E Nel; J Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I Zink
Journal:  J Am Ceram Soc       Date:  2009-01-01       Impact factor: 3.784
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