| Literature DB >> 20729853 |
Li-Dong Wang1, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, Xin Song, Yan Jin, Jiang-Man Li, Guo-Qiang Kong, Hong Qi, Juan Cui, Lian-Qun Zhang, Jie-Zhi Yang, Ji-Lin Li, Xing-Chuan Li, Jing-Li Ren, Zhi-Cai Liu, Wen-Jun Gao, Ling Yuan, Wu Wei, Yan-Rui Zhang, Wei-Peng Wang, Ilyar Sheyhidin, Feng Li, Bao-Ping Chen, Shu-Wei Ren, Bin Liu, Dan Li, Jian-Wei Ku, Zong-Min Fan, Sheng-Li Zhou, Zhi-Gang Guo, Xue-Ke Zhao, Na Liu, Yong-Hong Ai, Fang-Fang Shen, Wen-Yan Cui, Shuang Song, Tao Guo, Jing Huang, Chao Yuan, Jia Huang, Yue Wu, Wen-Bin Yue, Chang-Wei Feng, Hong-Lei Li, Yan Wang, Jin-Ya Tian, Yue Lu, Yi Yuan, Wen-Liang Zhu, Min Liu, Wen-Jing Fu, Xia Yang, Han-Jing Wang, Suo-Li Han, Jie Chen, Min Han, Hai-Yan Wang, Peng Zhang, Xiu-Min Li, Jin-Cheng Dong, Guo-Lan Xing, Ran Wang, Ming Guo, Zhi-Wei Chang, Hai-Lin Liu, Li Guo, Zhi-Qing Yuan, Hai Liu, Qin Lu, Liu-Qin Yang, Fu-Guo Zhu, Xiu-Feng Yang, Xiao-Shan Feng, Zhou Wang, Yin Li, She-Gan Gao, Qirenwang Qige, Long-Tang Bai, Wen-Jun Yang, Guang-Yan Lei, Zhong-Ying Shen, Long-Qi Chen, En-Min Li, Li-Yan Xu, Zhi-Yong Wu, Wei-Ke Cao, Jian-Po Wang, Zhi-Qin Bao, Ji-Li Chen, Guang-Cheng Ding, Xiang Zhuang, Ying-Fa Zhou, Hou-Feng Zheng, Zheng Zhang, Xian-Bo Zuo, Zi-Ming Dong, Dong-Mei Fan, Xin He, Jin Wang, Qi Zhou, Qin-Xian Zhang, Xin-Ying Jiao, Shi-Yong Lian, Ai-Fang Ji, Xiao-Mei Lu, Jin-Sheng Wang, Fu-Bao Chang, Chang-Dong Lu, Zhi-Guo Chen, Jian-Jun Miao, Zeng-Lin Fan, Ruo-Bai Lin, Tai-Jiang Liu, Jin-Chang Wei, Qing-Peng Kong, Yu Lan, Yu-Jing Fan, Fu-Sheng Gao, Tian-Yun Wang, Dong Xie, Shu-Qing Chen, Wan-Cai Yang, Jun-Yan Hong, Liang Wang, Song-Liang Qiu, Zhi-Ming Cai, Xue-Jun Zhang.
Abstract
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.Entities:
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Year: 2010 PMID： 20729853 DOI： 10.1038/ng.648
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330