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Literature DB >> 20729113

Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse.

Brenda J Polster¹, Shawn K Westaway, Thuy M Nguyen, Moon Y Yoon, Susan J Hayflick.

Abstract

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20729113 PMCID： PMC2951883 DOI： 10.1016/j.ymgme.2010.07.016

Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797

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