Literature DB >> 20728965

Synthesis of new pyrazole derivatives and their anticancer evaluation.

George Mihai Nitulescu1, Constantin Draghici, Alexandru Vasile Missir.   

Abstract

A series of functionally substituted pyrazole compounds have been synthesized and evaluated in vitro for their antiproliferative effects on a panel of 60 cellular lines, according to the National Cancer Institute screening protocol. Three of the 12 tested compounds showed moderate antitumor activity, one of them being chosen for the 5-dose assay and presented logGI(50) values up to -5.75.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20728965     DOI： 10.1016/j.ejmech.2010.07.064

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

Review 1.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

2.  An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity.

Authors:  Fariba Peytam; Mehdi Adib; Reihaneh Shourgeshty; Loghman Firoozpour; Mahmoud Rahmanian-Jazi; Mehdi Jahani; Setareh Moghimi; Kouros Divsalar; Mohammad Ali Faramarzi; Somayeh Mojtabavi; Fatemeh Safari; Mohammad Mahdavi; Alireza Foroumadi
Journal:  Sci Rep       Date:  2020-02-13       Impact factor: 4.379

Review 3.  Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery.

Authors:  Vuyolwethu Khwaza; Sithenkosi Mlala; Opeoluwa O Oyedeji; Blessing A Aderibigbe
Journal:  Molecules       Date:  2021-04-21       Impact factor: 4.411

4.  New potential antitumor pyrazole derivatives: synthesis and cytotoxic evaluation.

Authors:  George Mihai Nitulescu; Constantin Draghici; Octavian Tudorel Olaru
Journal:  Int J Mol Sci       Date:  2013-11-04       Impact factor: 5.923

5.  Synthesis, Molecular Docking and in Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine⁻Pyrazole Hybrid Derivatives.

Authors:  Eman M Flefel; Walaa I El-Sofany; Mahmoud El-Shahat; Arshi Naqvi; Eman Assirey
Journal:  Molecules       Date:  2018-10-06       Impact factor: 4.411

6.  A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis.

Authors:  Hong Wang; Jinhong Zheng; Weijie Xu; Cheng Chen; Duncan Wei; Wenxiu Ni; Ying Pan
Journal:  Molecules       Date:  2017-09-29       Impact factor: 4.411

7.  Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.

Authors:  Denisse A Gutierrez; Lisett Contreras; Paulina J Villanueva; Edgar A Borrego; Karla Morán-Santibañez; Jessica D Hess; Rebecca DeJesus; Manuel Larragoity; Ana P Betancourt; Jonathon E Mohl; Elisa Robles-Escajeda; Khodeza Begum; Sourav Roy; Robert A Kirken; Armando Varela-Ramirez; Renato J Aguilera
Journal:  Cells       Date:  2022-01-12       Impact factor: 6.600
  7 in total

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