| Literature DB >> 20727748 |
Eric D Jones1, Nick Vandegraaff, Giang Le, Neil Choi, William Issa, Katherine Macfarlane, Neeranat Thienthong, Lisa J Winfield, Jonathan A V Coates, Long Lu, Xinming Li, Xiao Feng, Changjiang Yu, David I Rhodes, John J Deadman.
Abstract
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC(50) of 3 nM against wild type HIV infected T-cells.Entities:
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Year: 2010 PMID： 20727748 DOI： 10.1016/j.bmcl.2010.07.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823