Literature DB >> 30108723

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against Klebsiella pneumoniae.

Rong Wang1, Shuang Hou1, Xiaojing Dong2, Daijie Chen2, Lei Shao3, Liujia Qian3, Zhong Li1,4, Xiaoyong Xu1,4.   

Abstract

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

Entities:  

Year:  2017        PMID： 30108723      PMCID： PMC6071964          DOI： 10.1039/c7md00354d

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  25 in total

1.  Synthesis and in silico investigation of thiazoles bearing pyrazoles derivatives as anti-inflammatory agents.

Authors:  Rahul D Kamble; Rohan J Meshram; Shrikant V Hese; Rahul A More; Sonali S Kamble; Rajesh N Gacche; Bhaskar S Dawane
Journal:  Comput Biol Chem       Date:  2016-01-23       Impact factor: 2.877

2.  Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells.

Authors:  Thiago André R Dos Santos; Aline Caroline da Silva; Elany Barbosa Silva; Paulo André Teixeira de Moraes Gomes; José Wanderlan Pontes Espíndola; Marcos Veríssimo de Oliveira Cardoso; Diogo Rodrigo Magalhaes Moreira; Ana Cristina Lima Leite; Valéria R A Pereira
Journal:  Biomed Pharmacother       Date:  2016-06-06       Impact factor: 6.529

3.  Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.

Authors:  Nusaibah Abdul Rahim; Soon-Ee Cheah; Matthew D Johnson; Heidi Yu; Hanna E Sidjabat; John Boyce; Mark S Butler; Matthew A Cooper; Jing Fu; David L Paterson; Roger L Nation; Phillip J Bergen; Tony Velkov; Jian Li
Journal:  J Antimicrob Chemother       Date:  2015-05-28       Impact factor: 5.790

4.  Antibacterial and anti-biofilm activities of melittin and colistin, alone and in combination with antibiotics against Gram-negative bacteria.

Authors:  Sibel Dosler; Elif Karaaslan; A Alev Gerceker
Journal:  J Chemother       Date:  2016-04       Impact factor: 1.714

Review 5.  Complement resistance mechanisms of Klebsiella pneumoniae.

Authors:  Dennis J Doorduijn; Suzan H M Rooijakkers; Willem van Schaik; Bart W Bardoel
Journal:  Immunobiology       Date:  2016-06-16       Impact factor: 3.144

6.  In Vitro Antibacterial Activity of Curcumin-Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections.

Authors:  Jonathan W Betts; Amir S Sharili; Roberto M La Ragione; David W Wareham
Journal:  J Nat Prod       Date:  2016-06-13       Impact factor: 4.050

7.  Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin.

Authors:  Martti Vaara; Osmo Siikanen; Juha Apajalahti; Niels Frimodt-Møller; Timo Vaara
Journal:  J Antimicrob Chemother       Date:  2010-02-18       Impact factor: 5.790

8.  The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria.

Authors:  Lorraine A Draper; Paul D Cotter; Colin Hill; R Paul Ross
Journal:  BMC Microbiol       Date:  2013-09-26       Impact factor: 3.605

9.  Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.

Authors:  Andrew M King; Sarah A Reid-Yu; Wenliang Wang; Dustin T King; Gianfranco De Pascale; Natalie C Strynadka; Timothy R Walsh; Brian K Coombes; Gerard D Wright
Journal:  Nature       Date:  2014-06-26       Impact factor: 49.962

10.  Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression.

Authors:  Wenhui Cai; Yingmei Fu; Wenli Zhang; Xiaobei Chen; Jizi Zhao; Wuqi Song; Yujun Li; Ying Huang; Zheng Wu; Rui Sun; Chunping Dong; Fengmin Zhang
Journal:  BMC Microbiol       Date:  2016-08-08       Impact factor: 3.605
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