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Literature DB >> 20725594

Enantioselective syntheses of both enantiomers of cis-pyrrolidine 225H.

Hong Shu¹, April R Noble, Suhong Zhang, Lei Miao, Mark L Trudell.

Abstract

The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloid cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R).

Entities: Chemical Disease Species

Year: 2010 PMID： 20725594 PMCID： PMC2922008 DOI： 10.1016/j.tet.2010.04.037

Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457

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References

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Enantioselective syntheses of both enantiomers of cis-pyrrolidine 225H.

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