The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloid cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R).
The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloidn class="Chemical">cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R).
Authors: Tappey H Jones; Heather L Voegtle; Heather M Miras; Robert G Weatherford; Thomas F Spande; H Martin Garraffo; John W Daly; Diane W Davidson; Roy R Snelling Journal: J Nat Prod Date: 2007-01-23 Impact factor: 4.050
Authors: J W Daly; T F Spande; N Whittaker; R J Highet; D Feigl; N Nishimori; T Tokuyama; C W Myers Journal: J Nat Prod Date: 1986 Mar-Apr Impact factor: 4.050