Literature DB >> 20722369

Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines.

Animesh Ghosh1, Koushik Mukherjee, Xinpeng Jiang, Ying Zhou, Joshua McCarroll, James Qu, Pamela M Swain, Huricha Baigude, Tariq M Rana.   

Abstract

RNA interference (RNAi) is a gene-silencing phenomenon whereby double-stranded RNA (dsRNA) triggers the sequence-specific degradation of homologous mRNA. RNAi has been quickly and widely applied to discover gene functions and holds great potential to provide a new class of therapeutic agents. However, new chemistry and delivery approaches are greatly needed to silence disease-causing genes without toxic effects. We reasoned that conjugation of the cholesterol moiety to cationic lipids would enhance RNAi efficiencies and lower the toxic effects of lipid-mediated RNAi delivery. Here, we report the first design and synthesis of new cholesterol-conjugated cationic lipids for RNAi delivery using microwave-assisted quaternization (MAQ) of tertiary amines. This strategy can be employed to develop new classes of nonviral gene delivery agents under safe and fast reaction conditions.

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Year:  2010        PMID： 20722369      PMCID： PMC3012264          DOI： 10.1021/bc900482r

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  25 in total

1.  Silencing of microRNAs in vivo with 'antagomirs'.

Authors:  Jan Krützfeldt; Nikolaus Rajewsky; Ravi Braich; Kallanthottathil G Rajeev; Thomas Tuschl; Muthiah Manoharan; Markus Stoffel
Journal:  Nature       Date:  2005-10-30       Impact factor: 49.962

Review 2.  Toward rapid, "green", predictable microwave-assisted synthesis.

Authors:  Brett A Roberts; Christopher R Strauss
Journal:  Acc Chem Res       Date:  2005-08       Impact factor: 22.384

Review 3.  Illuminating the silence: understanding the structure and function of small RNAs.

Authors:  Tariq M Rana
Journal:  Nat Rev Mol Cell Biol       Date:  2007-01       Impact factor: 94.444

4.  A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium.

Authors:  A Santel; M Aleku; O Keil; J Endruschat; V Esche; G Fisch; S Dames; K Löffler; M Fechtner; W Arnold; K Giese; A Klippel; J Kaufmann
Journal:  Gene Ther       Date:  2006-04-20       Impact factor: 5.250

5.  An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.

Authors:  Deborah Palliser; Dipanjan Chowdhury; Qing-Yin Wang; Sandra J Lee; Roderick T Bronson; David M Knipe; Judy Lieberman
Journal:  Nature       Date:  2005-11-23       Impact factor: 49.962

6.  RNAi-mediated gene silencing in non-human primates.

Authors:  Tracy S Zimmermann; Amy C H Lee; Akin Akinc; Birgit Bramlage; David Bumcrot; Matthew N Fedoruk; Jens Harborth; James A Heyes; Lloyd B Jeffs; Matthias John; Adam D Judge; Kieu Lam; Kevin McClintock; Lubomir V Nechev; Lorne R Palmer; Timothy Racie; Ingo Röhl; Stephan Seiffert; Sumi Shanmugam; Vandana Sood; Jürgen Soutschek; Ivanka Toudjarska; Amanda J Wheat; Ed Yaworski; William Zedalis; Victor Koteliansky; Muthiah Manoharan; Hans-Peter Vornlocher; Ian MacLachlan
Journal:  Nature       Date:  2006-03-26       Impact factor: 49.962

7.  Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.

Authors:  Erwei Song; Pengcheng Zhu; Sang-Kyung Lee; Dipanjan Chowdhury; Steven Kussman; Derek M Dykxhoorn; Yi Feng; Deborah Palliser; David B Weiner; Premlata Shankar; Wayne A Marasco; Judy Lieberman
Journal:  Nat Biotechnol       Date:  2005-05-22       Impact factor: 54.908

8.  Design and creation of new nanomaterials for therapeutic RNAi.

Authors:  Huricha Baigude; Joshua McCarroll; Chao-shun Yang; Pamela M Swain; Tariq M Rana
Journal:  ACS Chem Biol       Date:  2007-04-24       Impact factor: 5.100

9.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors:  Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

10.  Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.

Authors:  Chia-ying Chu; Tariq M Rana
Journal:  PLoS Biol       Date:  2006-07       Impact factor: 8.029
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  4 in total

Review 1.  Gene regulation by non-coding RNAs.

Authors:  Veena S Patil; Rui Zhou; Tariq M Rana
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-10-28       Impact factor: 8.250

2.  Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading.

Authors:  Zhongzheng Ma; Yang Zheng; Zijian Chao; Hongtao Chen; Yunhui Zhang; Meizhen Yin; Jie Shen; Shuo Yan
Journal:  J Nanobiotechnology       Date:  2022-03-09       Impact factor: 10.435

3.  Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization.

Authors:  Ruilong Sheng; Zhao Wang; Ting Luo; Amin Cao; Jingjing Sun; Joseph M Kinsella
Journal:  Int J Mol Sci       Date:  2018-01-26       Impact factor: 5.923

4.  Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids.

Authors:  Ehexige Ehexige; Tsogzolmaa Ganbold; Xiang Yu; Shuqin Han; Huricha Baigude
Journal:  Molecules       Date:  2019-09-19       Impact factor: 4.411
  4 in total

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