Literature DB >> 20721640

A new functional role of HIV-1 integrase during uncoating of the viral core.

Marisa S Briones1, Samson A Chow.   

Abstract

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.

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Year:  2010        PMID： 20721640     DOI： 10.1007/s12026-010-8164-z

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  130 in total

1.  Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.

Authors:  A Fassati; S P Goff
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

2.  Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.

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Journal:  Nat Struct Biol       Date:  1997-07

Review 3.  Retroviral integrases and their cousins.

Authors:  P Rice; R Craigie; D R Davies
Journal:  Curr Opin Struct Biol       Date:  1996-02       Impact factor: 6.809

4.  Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity.

Authors:  Zuzana Keckesova; Laura M J Ylinen; Greg J Towers
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

5.  Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.

Authors:  Elena Sokolskaja; Lionel Berthoux; Jeremy Luban
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

Review 6.  Bacterial transposases and retroviral integrases.

Authors:  P Polard; M Chandler
Journal:  Mol Microbiol       Date:  1995-01       Impact factor: 3.501

7.  Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins.

Authors:  Ryuta Sakuma; Josh A Noser; Seiga Ohmine; Yasuhiro Ikeda
Journal:  Nat Med       Date:  2007-04-15       Impact factor: 53.440

8.  Restriction of lentivirus in monkeys.

Authors:  Caroline Besnier; Yasuhiro Takeuchi; Greg Towers
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-01       Impact factor: 11.205

9.  Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

Authors:  Barbie K Ganser-Pornillos; Anchi Cheng; Mark Yeager
Journal:  Cell       Date:  2007-10-05       Impact factor: 41.582

10.  Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells.

Authors:  Masahiro Yamashita; Omar Perez; Thomas J Hope; Michael Emerman
Journal:  PLoS Pathog       Date:  2007-10-26       Impact factor: 6.823
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  5 in total

1.  Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

Authors:  Jacques J Kessl; Nivedita Jena; Yasuhiro Koh; Humeyra Taskent-Sezgin; Alison Slaughter; Lei Feng; Suresh de Silva; Li Wu; Stuart F J Le Grice; Alan Engelman; James R Fuchs; Mamuka Kvaratskhelia
Journal:  J Biol Chem       Date:  2012-03-21       Impact factor: 5.157

2.  Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.

Authors:  Xiang Li; Yasuhiro Koh; Alan Engelman
Journal:  J Virol       Date:  2012-01-25       Impact factor: 5.103

3.  Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.

Authors:  Shewit S Tekeste; Thomas A Wilkinson; Ethan M Weiner; Xiaowen Xu; Jennifer T Miller; Stuart F J Le Grice; Robert T Clubb; Samson A Chow
Journal:  J Virol       Date:  2015-09-23       Impact factor: 5.103

4.  INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo.

Authors:  Sheeba Mathew; Minh Nguyen; Xuhong Wu; Achintya Pal; Vaibhav B Shah; Vinayaka R Prasad; Christopher Aiken; Ganjam V Kalpana
Journal:  Retrovirology       Date:  2013-06-24       Impact factor: 4.602

5.  An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability.

Authors:  Annalena La Porte; Jennifer Cano; Xuhong Wu; Doyel Mitra; Ganjam V Kalpana
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103
  5 in total

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