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Literature DB >> 20717474

A Diels-Alder Route to Angularly Functionalized Bicyclic Structures.

Woo Han Kim¹, Jun Hee Lee, Baptiste Aussedat, Samuel J Danishefsky.

Abstract

A Diels-Alder based route to trans-fused angularly functionalized bicyclic structures has been developed. This transformation features the use of a tetrasubstituted dienophile in the cycloaddition step.

Entities: Chemical Disease Gene Species

Year: 2010 PMID： 20717474 PMCID： PMC2921539 DOI： 10.1016/j.tet.2010.04.094

Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457

6 in total

1. Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

Authors: Ohyun Kwon; Seung Bum Park; Stuart L Schreiber
Journal: J Am Chem Soc Date: 2002-11-13 Impact factor: 15.419

2. An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position.

Authors: Jun Hee Lee; Woo Han Kim; Samuel J Danishefsky
Journal: Tetrahedron Lett Date: 2010-03-03 Impact factor: 2.415

3. Total Synthesis of Colombiasin A.

Authors: K C Nicolaou; Georgios Vassilikogiannakis; Wolfgang Mägerlein; Remo Kranich
Journal: Angew Chem Int Ed Engl Date: 2001-07-02 Impact factor: 15.336

Review 4. The Catalytic Enantioselective Construction of Molecules with Quaternary Carbon Stereocenters.

Authors: Elias J Corey; Angel Guzman-Perez
Journal: Angew Chem Int Ed Engl Date: 1998-03-02 Impact factor: 15.336

5. Catalytic asymmetric synthesis of all-carbon quaternary stereocenters.

Authors: Christopher J Douglas; Larry E Overman
Journal: Proc Natl Acad Sci U S A Date: 2004-01-14 Impact factor: 11.205

6. Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm.

Authors: Woo Han Kim; Jun Hee Lee; Samuel J Danishefsky
Journal: J Am Chem Soc Date: 2009-09-09 Impact factor: 15.419

6 in total

4 in total

A Diels-Alder Route to Angularly Functionalized Bicyclic Structures.

1. Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

2. An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position.

3. Total Synthesis of Colombiasin A.

Review 4. The Catalytic Enantioselective Construction of Molecules with Quaternary Carbon Stereocenters.

5. Catalytic asymmetric synthesis of all-carbon quaternary stereocenters.

6. Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm.

1. Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels-Alder motifs.

2. A straightforward route to functionalized trans-Diels-Alder motifs.

3. Further Expansion of the trans-Diels-Alder Paradigm: Reductive Alkylation of α-Cyanoketones.

4. Synthesis of angularly substituted trans-fused hydroindanes by convergent coupling of acyclic precursors.