Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.

Literature DB >> 20717123

Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.

Konstantinos Stellos¹, Victoria Panagiota, Andreas Kögel, Thomas Leyhe, Meinrad Gawaz, Christoph Laske.

Abstract

Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20717123 PMCID： PMC3023934 DOI： 10.1038/jcbfm.2010.140

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

16 in total

1. Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication.

Authors: K Stellos; B Bigalke; D Stakos; N Henkelmann; M Gawaz
Journal: J Thromb Haemost Date: 2009-10-23 Impact factor: 5.824

2. Platelet APP isoform ratios correlate with declining cognition in AD.

Authors: F Baskin; R N Rosenberg; L Iyer; L Hynan; C M Cullum
Journal: Neurology Date: 2000-05-23 Impact factor: 9.910

3. Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.

Authors: D S Houston; J T Shepherd; P M Vanhoutte
Journal: J Clin Invest Date: 1986-08 Impact factor: 14.808

4. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.

Authors: Françoise Forette; Marie-Laure Seux; Jan A Staessen; Lutgarde Thijs; Marija-Ruta Babarskiene; Speranta Babeanu; Alfredo Bossini; Robert Fagard; Blas Gil-Extremera; Tovio Laks; Zhanna Kobalava; Cinzia Sarti; Jaakko Tuomilehto; Hannu Vanhanen; John Webster; Yair Yodfat; Willem H Birkenhäger
Journal: Arch Intern Med Date: 2002-10-14

5. Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease.

Authors: C M Clark; L Sheppard; G G Fillenbaum; D Galasko; J C Morris; E Koss; R Mohs; A Heyman
Journal: Arch Neurol Date: 1999-07

6. Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community.

Authors: Laure Carcaillon; Karine Pérès; Jean-Jacques Péré; Catherine Helmer; Jean-Marc Orgogozo; Jean-François Dartigues
Journal: Dement Geriatr Cogn Disord Date: 2007-04-26 Impact factor: 2.959

7. Dementia in stroke survivors in the Stroke Data Bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings.

Authors: T K Tatemichi; M A Foulkes; J P Mohr; J R Hewitt; D B Hier; T R Price; P A Wolf
Journal: Stroke Date: 1990-06 Impact factor: 7.914

8. Treatment of a whole population sample of Alzheimer's disease with donepezil over a 4-year period: lessons learned.

Authors: Sarah Lyle; Moni Grizzell; Sasi Willmott; Susan Benbow; Michael Clark; David Jolley
Journal: Dement Geriatr Cogn Disord Date: 2008-01-30 Impact factor: 2.959

9. Rate of progression in Alzheimer's disease correlates with coated-platelet levels--a longitudinal study.

Authors: Calin I Prodan; Elliott D Ross; Andrea S Vincent; George L Dale
Journal: Transl Res Date: 2008-08-09 Impact factor: 7.012

10. Hyperresponsiveness of platelets in ischemic stroke.

Authors: Suzanne Fateh-Moghadam; Patrik Htun; Bernd Tomandl; Dirk Sander; Konstantinos Stellos; Tobias Geisler; Harald Langer; Kodwo Walton; Rene Handschu; Christoph Garlichs; Werner G Daniel; Meinrad Gawaz
Journal: Thromb Haemost Date: 2007-06 Impact factor: 5.249

27 in total

1. Platelet decline as a predictor of brain injury in HIV infection.

Authors: Ann B Ragin; Gypsyamber D'Souza; Sandra Reynolds; Eric Miller; Ned Sacktor; Ola A Selnes; Eileen Martin; Barbara R Visscher; James T Becker
Journal: J Neurovirol Date: 2011-09-29 Impact factor: 2.643

Review 2. Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Authors: Geneviève Evin; Qiao-Xin Li
Journal: World J Psychiatry Date: 2012-12-22

3. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.

Authors: Heide Loehlein Fier; Dmitry Prokopenko; Julian Hecker; Michael H Cho; Edwin K Silverman; Scott T Weiss; Rudolph E Tanzi; Christoph Lange
Journal: Genet Epidemiol Date: 2017-03-20 Impact factor: 2.135

4. Biomarkers of Alzheimer's disease among Mexican Americans.

Authors: Sid E O'Bryant; Guanghua Xiao; Melissa Edwards; Michael Devous; Veer Bala Gupta; Ralph Martins; Fan Zhang; Robert Barber
Journal: J Alzheimers Dis Date: 2013 Impact factor: 4.472

5. Multiple loci influencing hippocampal degeneration identified by genome scan.

Authors: Scott A Melville; Jacqueline Buros; Antonio R Parrado; Badri Vardarajan; Mark W Logue; Li Shen; Shannon L Risacher; Sungeun Kim; Gyungah Jun; Charles DeCarli; Kathryn L Lunetta; Clinton T Baldwin; Andrew J Saykin; Lindsay A Farrer
Journal: Ann Neurol Date: 2012-06-28 Impact factor: 10.422

Review 6. BACE1 as a potential biomarker for Alzheimer's disease.

Authors: Boris Decourt; Marwan N Sabbagh
Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472

7. Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.

Authors: Zhouxian Bai; Boryana Stamova; Huichun Xu; Bradley P Ander; Jiajia Wang; Glen C Jickling; Xinhua Zhan; DaZhi Liu; Guangchun Han; Lee-Way Jin; Charles DeCarli; Hongxing Lei; Frank R Sharp
Journal: Alzheimer Dis Assoc Disord Date: 2014 Jul-Sep Impact factor: 2.703