Literature DB >> 20714568

Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.

Chengshan Wang1, Nilam Shah, Garima Thakur, Feimeng Zhou, Roger M Leblanc.   

Abstract

Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein.

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Year:  2010        PMID： 20714568      PMCID： PMC3186058          DOI： 10.1039/c0cc02098b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

1.  Low dielectric permittivity of water at the membrane interface: effect on the energy coupling mechanism in biological membranes.

Authors:  Dmitry A Cherepanov; Boris A Feniouk; Wolfgang Junge; Armen Y Mulkidjanian
Journal:  Biophys J       Date:  2003-08       Impact factor: 4.033

Review 2.  Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

Authors:  Elena Gaggelli; Henryk Kozlowski; Daniela Valensin; Gianni Valensin
Journal:  Chem Rev       Date:  2006-06       Impact factor: 60.622

3.  Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds: Two New Pleated Sheets.

Authors:  L Pauling; R B Corey
Journal:  Proc Natl Acad Sci U S A       Date:  1951-11       Impact factor: 11.205

4.  Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements.

Authors:  Peter Borbat; Trudy F Ramlall; Jack H Freed; David Eliezer
Journal:  J Am Chem Soc       Date:  2006-08-09       Impact factor: 15.419

5.  Determination of alpha-synuclein concentration in human plasma using ELISA.

Authors:  A Winther Fjorback; K Varming; P Henning Jensen
Journal:  Scand J Clin Lab Invest       Date:  2007       Impact factor: 1.713

6.  Infrared reflection-absorption spectroscopy and polarization-modulated infrared reflection-absorption spectroscopy studies of the aequorin langmuir monolayer.

Authors:  Chengshan Wang; Miodrag Micic; Mark Ensor; Sylvia Daunert; Roger M Leblanc
Journal:  J Phys Chem B       Date:  2008-03-07       Impact factor: 2.991

7.  A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process.

Authors:  Dianlu Jiang; Kim Lien Dinh; Travis C Ruthenburg; Yi Zhang; Lei Su; Donald P Land; Feimeng Zhou
Journal:  J Phys Chem B       Date:  2009-03-12       Impact factor: 2.991

8.  Infrared reflection-absorption spectroscopy and polarization-modulated infrared reflection-absorption spectroscopy studies of the organophosphorus acid anhydrolase langmuir monolayer.

Authors:  Chengshan Wang; Jiayin Zheng; Liang Zhao; Vipin K Rastogi; Saumil S Shah; Joseph J DeFrank; Roger M Leblanc
Journal:  J Phys Chem B       Date:  2008-03-29       Impact factor: 2.991

9.  Lipid binding inhibits alpha-synuclein fibril formation.

Authors:  Min Zhu; Anthony L Fink
Journal:  J Biol Chem       Date:  2003-03-05       Impact factor: 5.157

10.  Modeling amyloid beta-peptide insertion into lipid bilayers.

Authors:  David L Mobley; Daniel L Cox; Rajiv R P Singh; Michael W Maddox; Marjorie L Longo
Journal:  Biophys J       Date:  2004-06       Impact factor: 4.033
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  8 in total

Review 1.  Protein particulate detection issues in biotherapeutics development--current status.

Authors:  Tapan K Das
Journal:  AAPS PharmSciTech       Date:  2012-05-08       Impact factor: 3.246

2.  Interfacial Properties of NTAIL, an Intrinsically Disordered Protein.

Authors:  Anaïs Bénarouche; Johnny Habchi; Alain Cagna; Ofelia Maniti; Agnès Girard-Egrot; Jean-François Cavalier; Sonia Longhi; Frédéric Carrière
Journal:  Biophys J       Date:  2017-12-19       Impact factor: 4.033

3.  Determine both the conformation and orientation of a specific residue in α-synuclein(61-95) even in monolayer by 13C isotopic label and p-polarized multiple-angle incidence resolution spectrometry (pMAIRS).

Authors:  Chengshan Wang; Yiqun Zhou; Christopher Ewuola; Toyin Akinleye; Takeshi Hasegawa; Roger M Leblanc
Journal:  Anal Sci       Date:  2022-05-28       Impact factor: 1.967

4.  Conversion of natively unstructured α-synuclein to its α-helical conformation significantly attenuates production of reactive oxygen species.

Authors:  Binbin Zhou; Yuanqiang Hao; Chengshan Wang; Ding Li; You-Nian Liu; Feimeng Zhou
Journal:  J Inorg Biochem       Date:  2012-09-08       Impact factor: 4.155

5.  Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.

Authors:  Giuliana Fusco; Alfonso De Simone; Paolo Arosio; Michele Vendruscolo; Gianluigi Veglia; Christopher M Dobson
Journal:  Sci Rep       Date:  2016-06-08       Impact factor: 4.379

6.  FT-IR Spectral Signature of Sensitive and Multidrug-Resistant Osteosarcoma Cell-Derived Extracellular Nanovesicles.

Authors:  Francesca Perut; Gabriela Graziani; Laura Roncuzzi; Nicoletta Zini; Sofia Avnet; Nicola Baldini
Journal:  Cells       Date:  2022-02-23       Impact factor: 6.600

7.  Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation.

Authors:  Alexander K Buell; Céline Galvagnion; Ricardo Gaspar; Emma Sparr; Michele Vendruscolo; Tuomas P J Knowles; Sara Linse; Christopher M Dobson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-09       Impact factor: 11.205

Review 8.  Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.

Authors:  Pablo Gracia; José D Camino; Laura Volpicelli-Daley; Nunilo Cremades
Journal:  Int J Mol Sci       Date:  2020-10-28       Impact factor: 5.923
  8 in total

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