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Literature DB >> 20712992

Actin filament length tunes elasticity of flexibly cross-linked actin networks.

K E Kasza¹, C P Broedersz, G H Koenderink, Y C Lin, W Messner, E A Millman, F Nakamura, T P Stossel, F C Mackintosh, D A Weitz.

Abstract

Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Entities: Chemical Disease Gene

Mesh：

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Year: 2010 PMID： 20712992 PMCID： PMC2920742 DOI： 10.1016/j.bpj.2010.06.025

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

41 in total

Review 1. Filamins as integrators of cell mechanics and signalling.

Authors: T P Stossel; J Condeelis; L Cooley; J H Hartwig; A Noegel; M Schleicher; S S Shapiro
Journal: Nat Rev Mol Cell Biol Date: 2001-02 Impact factor: 94.444

2. Stress-dependent elasticity of composite actin networks as a model for cell behavior.

Authors: M L Gardel; F Nakamura; J Hartwig; J C Crocker; T P Stossel; D A Weitz
Journal: Phys Rev Lett Date: 2006-03-03 Impact factor: 9.161

3. Viscoelasticity of isotropically cross-linked actin networks.

Authors: R Tharmann; M M A E Claessens; A R Bausch
Journal: Phys Rev Lett Date: 2007-02-21 Impact factor: 9.161

4. Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4.

Authors: Sabine M Volkmer Ward; Astrid Weins; Martin R Pollak; David A Weitz
Journal: Biophys J Date: 2008-08-08 Impact factor: 4.033

5. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.

Authors: Tiina Kainulainen; Alexandra Pender; Mario D'Addario; Yuanyi Feng; Predrag Lekic; Christopher A McCulloch
Journal: J Biol Chem Date: 2002-03-21 Impact factor: 5.157

6. Mechanical unfolding of single filamin A (ABP-280) molecules detected by atomic force microscopy.

Authors: S Furuike; T Ito; M Yamazaki
Journal: FEBS Lett Date: 2001-06-01 Impact factor: 4.124

7. Actin-binding protein requirement for cortical stability and efficient locomotion.

Authors: C C Cunningham; J B Gorlin; D J Kwiatkowski; J H Hartwig; P A Janmey; H R Byers; T P Stossel
Journal: Science Date: 1992-01-17 Impact factor: 47.728

8. Filamin A is essential for active cell stiffening but not passive stiffening under external force.

Authors: K E Kasza; F Nakamura; S Hu; P Kollmannsberger; N Bonakdar; B Fabry; T P Stossel; N Wang; D A Weitz
Journal: Biophys J Date: 2009-05-20 Impact factor: 4.033

9. Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin.

Authors: Fitzroy J Byfield; Qi Wen; Ilya Levental; Kerstin Nordstrom; Paulo E Arratia; R Tyler Miller; Paul A Janmey
Journal: Biophys J Date: 2009-06-17 Impact factor: 4.033

10. The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages.

Authors: J H Hartwig; P Shevlin
Journal: J Cell Biol Date: 1986-09 Impact factor: 10.539

31 in total

Review 10. Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?

Authors: Andrew J Sutherland-Smith
Journal: Biophys Rev Date: 2011-01-27

Actin filament length tunes elasticity of flexibly cross-linked actin networks.

Review 1. Filamins as integrators of cell mechanics and signalling.

2. Stress-dependent elasticity of composite actin networks as a model for cell behavior.

3. Viscoelasticity of isotropically cross-linked actin networks.

4. Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4.

5. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.

6. Mechanical unfolding of single filamin A (ABP-280) molecules detected by atomic force microscopy.

7. Actin-binding protein requirement for cortical stability and efficient locomotion.

8. Filamin A is essential for active cell stiffening but not passive stiffening under external force.

9. Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin.

10. The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages.

1. Imperfect asymmetry: The mechanism governing asymmetric partitioning of damaged cellular components during mitosis.

2. Stress controls the mechanics of collagen networks.

3. Nonlinear Actin Deformations Lead to Network Stiffening, Yielding, and Nonuniform Stress Propagation.

4. Balance between Force Generation and Relaxation Leads to Pulsed Contraction of Actomyosin Networks.

Review 5. Emergent complexity of the cytoskeleton: from single filaments to tissue.

Review 6. Mechanical Properties of the Cytoskeleton and Cells.

7. Random Fiber Networks With Superior Properties Through Network Topology Control.

8. Nonlinear viscoelasticity of actin transiently cross-linked with mutant α-actinin-4.

Review 9. Forcing cells into shape: the mechanics of actomyosin contractility.

Review 10. Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?