Literature DB >> 20708210

BST-2 mediated restriction of simian-human immunodeficiency virus.

Autumn Ruiz1, David Lau, Richard S Mitchell, M Sarah Hill, Kimberly Schmitt, John C Guatelli, Edward B Stephens.   

Abstract

Pathogenic simian-human immunodeficiency viruses (SHIV) contain HIV-1 Vpu and SIV Nef, both shown to counteract BST-2 (HM1.24; CD317; tetherin) inhibition of virus release in a species-specific manner. We show that human and pig-tailed BST-2 (ptBST-2) restrict SHIV. We found that sequential "humanization" of the transmembrane domain (TMD) of the pig-tailed BST-2 (ptBST-2) protein resulted in a fluctuation in sensitivity to HIV-1 Vpu. Our results also show that the length of the TMD in human and ptBST-2 proteins is important for BST-2 restriction and susceptibility to Vpu. Taken together, our results emphasize the importance of tertiary structure in BST-2 antagonism and suggests that the HIV-1 Vpu transmembrane domain may have additional functions in vivo unrelated to BST-2 antagonism.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20708210      PMCID： PMC4104713          DOI： 10.1016/j.virol.2010.07.021

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  32 in total

1.  Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques.

Authors:  Edward B Stephens; Coleen McCormick; Erik Pacyniak; Darcy Griffin; David M Pinson; Francis Sun; Warren Nothnick; Scott W Wong; Robert Gunderson; Nancy E J Berman; Dinesh K Singh
Journal:  Virology       Date:  2002-02-15       Impact factor: 3.616

2.  A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques.

Authors:  C McCormick-Davis; S B Dalton; D R Hout; D K Singh; N E Berman; C Yong; D M Pinson; L Foresman; E B Stephens
Journal:  Virology       Date:  2000-06-20       Impact factor: 3.616

3.  CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection.

Authors:  Anja Habermann; Jacomine Krijnse-Locker; Heike Oberwinkler; Manon Eckhardt; Stefanie Homann; Amy Andrew; Klaus Strebel; Hans-Georg Kräusslich
Journal:  J Virol       Date:  2010-02-10       Impact factor: 5.103

4.  Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

Authors:  M Y Chowers; C A Spina; T J Kwoh; N J Fitch; D D Richman; J C Guatelli
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

5.  Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques.

Authors:  Z Q Liu; S Muhkerjee; M Sahni; C McCormick-Davis; K Leung; Z Li; V H Gattone; C Tian; R W Doms; T L Hoffman; R Raghavan; O Narayan; E B Stephens
Journal:  Virology       Date:  1999-08-01       Impact factor: 3.616

6.  Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.

Authors:  C Aiken; D Trono
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

7.  Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS.

Authors:  S V Joag; Z Q Liu; E B Stephens; M S Smith; A Kumar; Z Li; C Wang; D Sheffer; F Jia; L Foresman; I Adany; J Lifson; H M McClure; O Narayan
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

8.  Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.

Authors:  J Ishikawa; T Kaisho; H Tomizawa; B O Lee; Y Kobune; J Inazawa; K Oritani; M Itoh; T Ochi; K Ishihara
Journal:  Genomics       Date:  1995-04-10       Impact factor: 5.736

9.  The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.

Authors:  Dinesh K Singh; Darcy M Griffin; Erik Pacyniak; Mollie Jackson; Michael J Werle; Bo Wisdom; Francis Sun; David R Hout; David M Pinson; Robert S Gunderson; Michael F Powers; Scott W Wong; Edward B Stephens
Journal:  Virology       Date:  2003-09-01       Impact factor: 3.616

10.  Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology.

Authors:  Sabine Kupzig; Viktor Korolchuk; Ruth Rollason; Anna Sugden; Andrew Wilde; George Banting
Journal:  Traffic       Date:  2003-10       Impact factor: 6.215
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  11 in total

1.  HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions.

Authors:  Mark Skasko; Yan Wang; Ye Tian; Andrey Tokarev; Jason Munguia; Autumn Ruiz; Edward B Stephens; Stanley J Opella; John Guatelli
Journal:  J Biol Chem       Date:  2011-11-09       Impact factor: 5.157

2.  BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1).

Authors:  Philip H Jones; Martina Maric; Marisa N Madison; Wendy Maury; Richard J Roller; Chioma M Okeoma
Journal:  Virology       Date:  2013-02-12       Impact factor: 3.616

3.  Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques.

Authors:  Ming Sang; Jin-Biao Liu; Ming Dai; Jian-Guo Wu; Wen-Zhe Ho
Journal:  Antiviral Res       Date:  2014-10-23       Impact factor: 5.970

4.  Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo.

Authors:  Masashi Shingai; Takeshi Yoshida; Malcolm A Martin; Klaus Strebel
Journal:  J Virol       Date:  2011-07-20       Impact factor: 5.103

5.  Simian-Human immunodeficiency viruses expressing chimeric subtype B/C Vpu proteins demonstrate the importance of the amino terminal and transmembrane domains in the rate of CD4(+) T cell loss in macaques.

Authors:  Autumn Ruiz; Kimberly Schmitt; Nathan Culley; Edward B Stephens
Journal:  Virology       Date:  2012-12-05       Impact factor: 3.616

6.  Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.

Authors:  Andrey A Tokarev; Jason Munguia; John C Guatelli
Journal:  J Virol       Date:  2010-10-27       Impact factor: 5.103

7.  Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene.

Authors:  Kristina Nikovics; Marie-Christine Dazza; Michel Ekwalanga; Fabrizio Mammano; François Clavel; Sentob Saragosti
Journal:  PLoS One       Date:  2012-04-17       Impact factor: 3.240

8.  BST2/tetherin inhibits dengue virus release from human hepatoma cells.

Authors:  Xiao-Ben Pan; Jin-Chao Han; Xu Cong; Lai Wei
Journal:  PLoS One       Date:  2012-12-07       Impact factor: 3.240

Review 9.  Modulation of HIV-1-host interaction: role of the Vpu accessory protein.

Authors:  Mathieu Dubé; Mariana G Bego; Catherine Paquay; Éric A Cohen
Journal:  Retrovirology       Date:  2010-12-22       Impact factor: 4.602

10.  A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.

Authors:  Zeyun Mi; Jiwei Ding; Quan Zhang; Jianyuan Zhao; Ling Ma; Haisheng Yu; Zhenlong Liu; Guangzhi Shan; Xiaoyu Li; Jinming Zhou; Tao Wei; Liguo Zhang; Fei Guo; Chen Liang; Shan Cen
Journal:  Sci Rep       Date:  2015-12-16       Impact factor: 4.379
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