Literature DB >> 23411007

BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1).

Philip H Jones1, Martina Maric, Marisa N Madison, Wendy Maury, Richard J Roller, Chioma M Okeoma.   

Abstract

Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted by Aedes mosquitoes. Infection with CHIKV elicits a type I interferon response that facilities virus clearance, probably through the action of down-stream effectors such as antiviral IFN-stimulated genes (ISGs). Bone marrow stromal antigen 2 (BST-2) is an ISG shown to restrict HIV-1 replication by preventing the infection of bystander cells by tethering progeny virions on the surface of infected cells. Here we show that enrichment of cell surface BST-2 results in retention of CHIKV virus like particles (VLPs) on the cell membrane. BST-2 was found to co-localize with CHIKV structural protein E1 in the context of VLPs without any noticeable effect on BST-2 level. However, CHIKV nonstructural protein 1 (nsP1) overcomes BST-2-mediated VLPs tethering by down-regulating BST-2 expression. We conclude that BST-2 tethers CHIKV VLPs on the host cell plasma membrane and identify CHIKV nsP1 as a novel BST-2 antagonist.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23411007      PMCID： PMC4086190          DOI： 10.1016/j.virol.2013.01.010

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  70 in total

1.  Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.

Authors:  Jelke J Fros; Wen Jun Liu; Natalie A Prow; Corinne Geertsema; Maarten Ligtenberg; Dana L Vanlandingham; Esther Schnettler; Just M Vlak; Andreas Suhrbier; Alexander A Khromykh; Gorben P Pijlman
Journal:  J Virol       Date:  2010-08-04       Impact factor: 5.103

2.  The beta-interferon promoter responds to priming through multiple independent regulatory elements.

Authors:  P King; S Goodbourn
Journal:  J Biol Chem       Date:  1994-12-02       Impact factor: 5.157

3.  Type I IFN controls chikungunya virus via its action on nonhematopoietic cells.

Authors:  Clémentine Schilte; Thérèse Couderc; Fabrice Chretien; Marion Sourisseau; Nicolas Gangneux; Florence Guivel-Benhassine; Anton Kraxner; Jürg Tschopp; Stephen Higgs; Alain Michault; Fernando Arenzana-Seisdedos; Marco Colonna; Lucie Peduto; Olivier Schwartz; Marc Lecuit; Matthew L Albert
Journal:  J Exp Med       Date:  2010-02-01       Impact factor: 14.307

4.  Association of the Sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1.

Authors:  S Mi; R Durbin; H V Huang; C M Rice; V Stollar
Journal:  Virology       Date:  1989-06       Impact factor: 3.616

5.  A novel block to mouse mammary tumor virus infection of lymphocytes in B10.BR mice.

Authors:  Chioma M Okeoma; Ming Shen; Susan R Ross
Journal:  J Virol       Date:  2007-11-14       Impact factor: 5.103

6.  Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.

Authors:  T Ahola; L Kääriäinen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-17       Impact factor: 11.205

7.  Processing the nonstructural polyproteins of sindbis virus: nonstructural proteinase is in the C-terminal half of nsP2 and functions both in cis and in trans.

Authors:  W R Hardy; J H Strauss
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

Review 8.  Modulation of HIV-1-host interaction: role of the Vpu accessory protein.

Authors:  Mathieu Dubé; Mariana G Bego; Catherine Paquay; Éric A Cohen
Journal:  Retrovirology       Date:  2010-12-22       Impact factor: 4.602

Review 9.  Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

Authors:  Anna Le Tortorec; Suzanne Willey; Stuart J D Neil
Journal:  Viruses       Date:  2011-05-06       Impact factor: 5.048

10.  Expression and evaluation of Chikungunya virus E1 and E2 envelope proteins for serodiagnosis of Chikungunya virus infection.

Authors:  Byungki Cho; Bo-Young Jeon; Jungho Kim; Jaesang Noh; Jiha Kim; Minjung Park; Sun Park
Journal:  Yonsei Med J       Date:  2008-10-31       Impact factor: 2.759
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  53 in total

1.  Distinct Roles of Interferon Alpha and Beta in Controlling Chikungunya Virus Replication and Modulating Neutrophil-Mediated Inflammation.

Authors:  Lindsey E Cook; Marissa C Locke; Alissa R Young; Kristen Monte; Matthew L Hedberg; Raeann M Shimak; Kathleen C F Sheehan; Deborah J Veis; Michael S Diamond; Deborah J Lenschow
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

2.  Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1.

Authors:  Na Zhang; Hongjian Zhao; Leiliang Zhang
Journal:  J Virol       Date:  2019-01-17       Impact factor: 5.103

3.  Semen Exosomes Promote Transcriptional Silencing of HIV-1 by Disrupting NF-κB/Sp1/Tat Circuitry.

Authors:  Jennifer L Welch; Hussein Kaddour; Patrick M Schlievert; Jack T Stapleton; Chioma M Okeoma
Journal:  J Virol       Date:  2018-10-12       Impact factor: 5.103

4.  BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.

Authors:  Philip H Jones; Wadie D Mahauad-Fernandez; Marisa N Madison; Chioma M Okeoma
Journal:  Virology       Date:  2013-06-25       Impact factor: 3.616

5.  Mechanism of Tetherin Inhibition of Alphavirus Release.

Authors:  Judy J Wan; Yaw Shin Ooi; Margaret Kielian
Journal:  J Virol       Date:  2019-03-21       Impact factor: 5.103

6.  Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

Authors:  Justin K Taylor; Christopher M Coleman; Sandra Postel; Jeanne M Sisk; John G Bernbaum; Thiagarajan Venkataraman; Eric J Sundberg; Matthew B Frieman
Journal:  J Virol       Date:  2015-09-16       Impact factor: 5.103

7.  TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner.

Authors:  K J Rogers; S Jones-Burrage; W Maury; S Mukhopadhyay
Journal:  Virology       Date:  2020-01-07       Impact factor: 3.616

8.  The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.

Authors:  Abdul A Waheed; Maya Swiderski; Ali Khan; Ariana Gitzen; Ahlam Majadly; Eric O Freed
Journal:  J Biol Chem       Date:  2020-04-14       Impact factor: 5.157

9.  The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses.

Authors:  Subhajit Poddar; Jennifer L Hyde; Matthew J Gorman; Michael Farzan; Michael S Diamond
Journal:  J Virol       Date:  2016-09-12       Impact factor: 5.103

10.  Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection.

Authors:  Wadie D Mahauad-Fernandez; Philip H Jones; Chioma M Okeoma
Journal:  J Gen Virol       Date:  2014-07-22       Impact factor: 3.891
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