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Literature DB >> 20706863

Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts.

O'Neal Copeland¹, Kristen J Nowak, Nigel G Laing, Gianina Ravenscroft, Andrew E Messer, Christopher R Bayliss, Steven B Marston.

Abstract

We have developed a quantitative antibody-based assay to measure the content of skeletal muscle alpha-actin relative to cardiac alpha-actin. We found 21 +/- 2% skeletal muscle alpha-actin content in normal heart muscle of adult man and mouse. In end stage failing heart 53 +/- 5% of striated actin was skeletal muscle alpha-actin and in samples of inter-ventricular septum from patients with hypertrophic obstructive cardiomyopathy (HOCM) skeletal muscle alpha-actin was 72 +/- 2% of sarcomeric actin. Thin filaments containing actin isolated from normal and HOCM heart muscle were functionally indistinguishable when studied by quantitative in vitro motility assay. We also found elevated skeletal muscle alpha-actin (60 +/- 7%) in a mouse model of dilated cardiomyopathy.

Entities: Disease Species

Mesh：

Substances：
Actins

Year: 2010 PMID： 20706863 DOI： 10.1007/s10974-010-9224-7

Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698

27 in total

1. Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle.

Authors: H Robert Bergen; Katalin Ajtai; Thomas P Burghardt; Angelito I Nepomuceno; David C Muddiman
Journal: Rapid Commun Mass Spectrom Date: 2003 Impact factor: 2.419

2. Role of the N-terminal negative charges of actin in force generation and cross-bridge kinetics in reconstituted bovine cardiac muscle fibres.

Authors: Xiaoying Lu; Mary K Bryant; Keith E Bryan; Peter A Rubenstein; Masataka Kawai
Journal: J Physiol Date: 2005-01-13 Impact factor: 5.182

Review 3. Thick filament proteins and performance in human heart failure.

Authors: Bradley M Palmer
Journal: Heart Fail Rev Date: 2005-09 Impact factor: 4.214

4. Troponin I and troponin T interact with troponin C to produce different Ca2+-dependent effects on actin-tropomyosin filament motility.

Authors: W Bing; I D Fraser; S B Marston
Journal: Biochem J Date: 1997-10-15 Impact factor: 3.857

5. Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.

Authors: K R Boheler; L Carrier; D de la Bastie; P D Allen; M Komajda; J J Mercadier; K Schwartz
Journal: J Clin Invest Date: 1991-07 Impact factor: 14.808

6. Genetic analysis of the interaction between cardiac and skeletal actin gene expression in striated muscle of the mouse.

Authors: S Alonso; I Garner; J Vandekerckhove; M Buckingham
Journal: J Mol Biol Date: 1990-02-20 Impact factor: 5.469

7. Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.

Authors: Adam M Jacques; O'Neal Copeland; Andrew E Messer; Clare E Gallon; Katie King; William J McKenna; Victor T Tsang; Steven B Marston
Journal: J Mol Cell Cardiol Date: 2008-06-04 Impact factor: 5.000

8. Alpha-skeletal actin is associated with increased contractility in the mouse heart.

Authors: T E Hewett; I L Grupp; G Grupp; J Robbins
Journal: Circ Res Date: 1994-04 Impact factor: 17.367

9. Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin.

Authors: Kristen J Nowak; Gianina Ravenscroft; Connie Jackaman; Aleksandra Filipovska; Stefan M Davies; Esther M Lim; Sarah E Squire; Allyson C Potter; Elizabeth Baker; Sophie Clément; Caroline A Sewry; Victoria Fabian; Kelly Crawford; James L Lessard; Lisa M Griffiths; John M Papadimitriou; Yun Shen; Grant Morahan; Anthony J Bakker; Kay E Davies; Nigel G Laing
Journal: J Cell Biol Date: 2009-05-25 Impact factor: 10.539

10. The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.

Authors: Adam M Jacques; Natalia Briceno; Andrew E Messer; Clare E Gallon; Shapour Jalilzadeh; Edwin Garcia; Gaelle Kikonda-Kanda; Jennifer Goddard; Sian E Harding; Hugh Watkins; M Tomé Esteban; Victor T Tsang; William J McKenna; Steven B Marston
Journal: Cardiovasc Res Date: 2008-04-14 Impact factor: 10.787

13 in total

1. A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress.

Authors: Ross Wilkinson; Weihua Song; Natalia Smoktunowicz; Steven Marston
Journal: Am J Physiol Heart Circ Physiol Date: 2015-10-02 Impact factor: 4.733

2. Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

Authors: Weihua Song; Emma Dyer; Daniel J Stuckey; O'Neal Copeland; Man-Ching Leung; Christopher Bayliss; Andrew Messer; Ross Wilkinson; Jordi Lopez Tremoleda; Michael D Schneider; Sian E Harding; Charles S Redwood; Kieran Clarke; Kristen Nowak; Lorenzo Monserrat; Dominic Wells; Steven B Marston
Journal: J Biol Chem Date: 2011-05-26 Impact factor: 5.157

Review 10. Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.

Authors: Andrew E Messer; Steven B Marston
Journal: Front Physiol Date: 2014-08-25 Impact factor: 4.566

Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts.

1. Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle.

2. Role of the N-terminal negative charges of actin in force generation and cross-bridge kinetics in reconstituted bovine cardiac muscle fibres.

Review 3. Thick filament proteins and performance in human heart failure.

4. Troponin I and troponin T interact with troponin C to produce different Ca2+-dependent effects on actin-tropomyosin filament motility.

5. Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.

6. Genetic analysis of the interaction between cardiac and skeletal actin gene expression in striated muscle of the mouse.

7. Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.

8. Alpha-skeletal actin is associated with increased contractility in the mouse heart.

9. Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin.

10. The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.

1. A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress.

2. Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

Review 3. How do mutations in contractile proteins cause the primary familial cardiomyopathies?

4. Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker.

Review 5. Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.

6. Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart.

7. Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches.

8. Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.

9. Tropomyosin isoform expression and phosphorylation in the human heart in health and disease.

Review 10. Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.