BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD. MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest-guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed. RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (P < .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (P < .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups. CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.
BACKGROUND AND PURPOSE:Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD. MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest-guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed. RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (P < .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (P < .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups. CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.
Authors: Ellison Fernando Cardoso; Fernanda Martins Maia; Felipe Fregni; Martin Luis Myczkowski; Luciano M Melo; João R Sato; Marco Antonio Marcolin; Sergio P Rigonatti; Antonio Cesário Cruz; Egberto Reis Barbosa; Edson Amaro Journal: Neuroimage Date: 2009-05-03 Impact factor: 6.556
Authors: D Y Lee; E Fletcher; O Martinez; M Ortega; N Zozulya; J Kim; J Tran; M Buonocore; O Carmichael; C DeCarli Journal: Neurology Date: 2009-10-21 Impact factor: 9.910
Authors: Stephen M Smith; Mark Jenkinson; Heidi Johansen-Berg; Daniel Rueckert; Thomas E Nichols; Clare E Mackay; Kate E Watkins; Olga Ciccarelli; M Zaheer Cader; Paul M Matthews; Timothy E J Behrens Journal: Neuroimage Date: 2006-04-19 Impact factor: 6.556
Authors: Devyn L Cotter; Samantha M Walters; Corrina Fonseca; Amy Wolf; Yann Cobigo; Emily C Fox; Michelle Y You; Marie Altendahl; Nina Djukic; Adam M Staffaroni; Fanny M Elahi; Joel H Kramer; Kaitlin B Casaletto Journal: Am J Geriatr Psychiatry Date: 2020-05-15 Impact factor: 4.105
Authors: P J Planetta; E T Schulze; E K Geary; D M Corcos; J G Goldman; D M Little; D E Vaillancourt Journal: AJNR Am J Neuroradiol Date: 2012-07-05 Impact factor: 3.825