Literature DB >> 20704414

Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate.

Jing Sun1, Er-Yan Xia, Qun Wu, Chao-Guo Yan.   

Abstract

A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.

Entities:  

Year:  2010        PMID： 20704414     DOI： 10.1021/ol101475b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  Regioselective four-component synthesis of new tetrazolo[1,5-a]quinoline-based 2-amino-1,4-dihydropyridine and pyridin-2(1H)-one derivatives using nano-ZnO catalysis.

Authors:  Tooran Aghaalizadeh; Farough Nasiri
Journal:  Mol Divers       Date:  2018-06-27       Impact factor: 2.943

2.  Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds.

Authors:  Yan Sun; Jing Sun; Chao-Guo Yan
Journal:  Mol Divers       Date:  2011-11-30       Impact factor: 2.943

3.  Synthesis of tetrahydropyrimidin-2-ones via FeCl3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea.

Authors:  Li-Li Zhang; Jing Sun; Chao-Guo Yan
Journal:  Mol Divers       Date:  2013-10-25       Impact factor: 2.943

4.  Efficient synthesis of functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] via one-pot three-component reaction.

Authors:  Chao Wang; Yan-Hong Jiang; Chao-Guo Yan
Journal:  Mol Divers       Date:  2014-07-31       Impact factor: 2.943

5.  Molecular diversity of acid-catalyzed one-pot reaction of arylamines, methyl propiolate, and isatins.

Authors:  Hong Gao; Jing Sun; Chao-Guo Yan
Journal:  Mol Divers       Date:  2014-03-25       Impact factor: 2.943

6.  Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate.

Authors:  Hong Gao; Jing Sun; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2013-12-27       Impact factor: 2.883

7.  Molecular diversity of the base-promoted reaction of phenacylmalononitriles with dialkyl but-2-ynedioates.

Authors:  Hui Zheng; Ying Han; Jing Sun; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2022-08-08       Impact factor: 2.544

8.  Synthesis of functionalized spiro[indoline-3,4'-pyridines] and spiro[indoline-3,4'-pyridinones] via one-pot four-component reactions.

Authors:  Li-Juan Zhang; Qun Wu; Jing Sun; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2013-05-02       Impact factor: 2.883

9.  Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes.

Authors:  Jing Sun; Hong Gao; Qun Wu; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2012-10-26       Impact factor: 2.883

10.  Regioselectivity and diastereoselectivity of three-component reaction of α-amino acid, dialkyl acetylenedicarboxylates and 2-arylidene-1,3-indanediones.

Authors:  Liang Chen; Jing Sun; Ying Huang; Yu Zhang; Chao-Guo Yan
Journal:  Sci Rep       Date:  2017-09-29       Impact factor: 4.379
  10 in total

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