PURPOSE: The obesity epidemic raises concerns about the impact of excessive and insufficient weight gain during pregnancy. METHODS: We examined the association between gestational weight gain (GWG) and preterm birth, term small- and large-for-gestational-age (SGA and LGA), term birthweight, and term primary Cesarean delivery, considering prepregnancy body mass index (BMI) and ethnicity in a cohort of 33,872 New York City residents who gave birth between 1995 and 2003 and delivered in hospitals elsewhere in New York State. RESULTS: Preterm birth (<37 weeks' gestation) showed a modest U-shaped relationship, with projected GWG of <10 kg and 20+ kg associated with odds ratios of 1.4 and 1.3, respectively, relative to 10 to 14 kg. The pattern was stronger for preterm birth <32 weeks' and for underweight women with low GWG and overweight/obese women with high GWG. Term SGA decreased and term LGA and birthweight increased monotonically with increasing GWG. Primary Cesarean delivery followed the same pattern as LGA, but less strongly. CONCLUSIONS: Although the study is limited by potential selection bias and measurement error, our findings support the contention that GWG may be a modifiable predictor of pregnancy outcome that warrants further investigation, particularly randomized trials, to assess whether the relation is causal.
PURPOSE: The obesity epidemic raises concerns about the impact of excessive and insufficient weight gain during pregnancy. METHODS: We examined the association between gestational weight gain (GWG) and preterm birth, term small- and large-for-gestational-age (SGA and LGA), term birthweight, and term primary Cesarean delivery, considering prepregnancy body mass index (BMI) and ethnicity in a cohort of 33,872 New York City residents who gave birth between 1995 and 2003 and delivered in hospitals elsewhere in New York State. RESULTS: Preterm birth (<37 weeks' gestation) showed a modest U-shaped relationship, with projected GWG of <10 kg and 20+ kg associated with odds ratios of 1.4 and 1.3, respectively, relative to 10 to 14 kg. The pattern was stronger for preterm birth <32 weeks' and for underweight women with low GWG and overweight/obesewomen with high GWG. Term SGA decreased and term LGA and birthweight increased monotonically with increasing GWG. Primary Cesarean delivery followed the same pattern as LGA, but less strongly. CONCLUSIONS: Although the study is limited by potential selection bias and measurement error, our findings support the contention that GWG may be a modifiable predictor of pregnancy outcome that warrants further investigation, particularly randomized trials, to assess whether the relation is causal.
Authors: M Voigt; R L Schild; M Mewitz; K T M Schneider; D Schnabel; V Hesse; S Straube Journal: Geburtshilfe Frauenheilkd Date: 2013-04 Impact factor: 2.915
Authors: Anne Marie Darling; Martha M Werler; David E Cantonwine; Wafaie W Fawzi; Thomas F McElrath Journal: Epidemiology Date: 2019-09 Impact factor: 4.822
Authors: William A Grobman; Yinglei Lai; Jay D Iams; Uma M Reddy; Brian M Mercer; George Saade; Alan T Tita; Dwight J Rouse; Yoram Sorokin; Ronald J Wapner; Kenneth J Leveno; Sean C Blackwell; M Sean Esplin; Jorge E Tolosa; John M Thorp; Steve N Caritis Journal: J Ultrasound Med Date: 2016-05-05 Impact factor: 2.153
Authors: Stephanie A Leonard; Lucia C Petito; Olof Stephansson; Jennifer A Hutcheon; Lisa M Bodnar; Mahasin S Mujahid; Yvonne Cheng; Barbara Abrams Journal: Ann Epidemiol Date: 2017-05-10 Impact factor: 3.797
Authors: Stephanie A Leonard; Jennifer A Hutcheon; Lisa M Bodnar; Lucia C Petito; Barbara Abrams Journal: Paediatr Perinat Epidemiol Date: 2017-12-27 Impact factor: 3.980
Authors: Michelle A Kominiarek; Elizabeth Lucio Gray; Heidi Vyhmeister; William Grobman; Melissa Simon Journal: J Midwifery Womens Health Date: 2018-05-14 Impact factor: 2.388