Literature DB >> 20700817

Analysis of deuterium relaxation-derived methyl axis order parameters and correlation with local structure.

A Mittermaier1, L E Kay, J D Forman-Kay.   

Abstract

Methyl axis (S2axis) and backbone NH (S2NH) order parameters derived from eight proteins have been analyzed. Similar distribution profiles for Ala S2axis and S2NH order parameters were observed. A good correlation between the two S2axis values of Val and Leu methyl groups is noted, although differences between order parameters can arise. The relation of S2axis or S2NH to solvent accessibility and packing density has also been investigated. Correlations are weak, likely reflecting the importance of collective, non-local motions in proteins. The lack of correlation between these simple structural parameters and dynamics emphasizes the importance of motional studies to fully characterize proteins.

Entities:  

Year:  1999        PMID： 20700817     DOI： 10.1023/A:1008387715167

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


  28 in total

1.  Relation between stability, dynamics and enzyme activity in 3-phosphoglycerate kinases from yeast and Thermus thermophilus.

Authors:  P G Varley; R H Pain
Journal:  J Mol Biol       Date:  1991-07-20       Impact factor: 5.469

2.  MOLMOL: a program for display and analysis of macromolecular structures.

Authors:  R Koradi; M Billeter; K Wüthrich
Journal:  J Mol Graph       Date:  1996-02

3.  Contributions to conformational entropy arising from bond vector fluctuations measured from NMR-derived order parameters: application to protein folding.

Authors:  D Yang; L E Kay
Journal:  J Mol Biol       Date:  1996-10-25       Impact factor: 5.469

4.  NMR evidence for slow collective motions in cyanometmyoglobin.

Authors:  J R Tolman; J M Flanagan; M A Kennedy; J H Prestegard
Journal:  Nat Struct Biol       Date:  1997-04

5.  A study of protein side-chain dynamics from new 2H auto-correlation and 13C cross-correlation NMR experiments: application to the N-terminal SH3 domain from drk.

Authors:  D Yang; A Mittermaier; Y K Mok; L E Kay
Journal:  J Mol Biol       Date:  1998-03-13       Impact factor: 5.469

6.  Structure of calmodulin refined at 2.2 A resolution.

Authors:  Y S Babu; C E Bugg; W J Cook
Journal:  J Mol Biol       Date:  1988-11-05       Impact factor: 5.469

7.  Time dependence of atomic fluctuations in proteins: analysis of local and collective motions in bovine pancreatic trypsin inhibitor.

Authors:  S Swaminathan; T Ichiye; W van Gunsteren; M Karplus
Journal:  Biochemistry       Date:  1982-10-12       Impact factor: 3.162

8.  Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.

Authors:  S M Pascal; A U Singer; G Gish; T Yamazaki; S E Shoelson; T Pawson; L E Kay; J D Forman-Kay
Journal:  Cell       Date:  1994-05-06       Impact factor: 41.582

9.  Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme.

Authors:  M Buck; J Boyd; C Redfield; D A MacKenzie; D J Jeenes; D B Archer; C M Dobson
Journal:  Biochemistry       Date:  1995-03-28       Impact factor: 3.162

10.  Refined crystal structure of troponin C from turkey skeletal muscle at 2.0 A resolution.

Authors:  O Herzberg; M N James
Journal:  J Mol Biol       Date:  1988-10-05       Impact factor: 5.469
View more
  26 in total

1.  Correlation times and adiabatic barriers for methyl rotation in SNase.

Authors:  David C Chatfield; Alberto Augsten; Cassian D'Cunha
Journal:  J Biomol NMR       Date:  2004-07       Impact factor: 2.835

2.  Prediction of methyl-side chain dynamics in proteins.

Authors:  Dengming Ming; Rafael Brüschweiler
Journal:  J Biomol NMR       Date:  2004-07       Impact factor: 2.835

3.  The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase.

Authors:  Anthony Mittermaier; Lewis E Kay
Journal:  Protein Sci       Date:  2004-04       Impact factor: 6.725

4.  Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered.

Authors:  Magnus Kjaergaard; Flemming M Poulsen; Kaare Teilum
Journal:  Biophys J       Date:  2012-04-03       Impact factor: 4.033

5.  Effect of hydrophobic core packing on sidechain dynamics.

Authors:  E C Johnson; T M Handel
Journal:  J Biomol NMR       Date:  1999-10       Impact factor: 2.835

6.  Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities.

Authors:  Virginia A Goehlert; Ewa Krupinska; Lynne Regan; Martin J Stone
Journal:  Protein Sci       Date:  2004-11-10       Impact factor: 6.725

7.  Relation between native ensembles and experimental structures of proteins.

Authors:  Robert B Best; Kresten Lindorff-Larsen; Mark A DePristo; Michele Vendruscolo
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-07       Impact factor: 11.205

8.  Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase cofactor P.

Authors:  Klaartje Houben; Laurence Blanchard; Martin Blackledge; Dominique Marion
Journal:  Biophys J       Date:  2007-06-22       Impact factor: 4.033

9.  A simple model of backbone flexibility improves modeling of side-chain conformational variability.

Authors:  Gregory D Friedland; Anthony J Linares; Colin A Smith; Tanja Kortemme
Journal:  J Mol Biol       Date:  2008-05-11       Impact factor: 5.469

10.  Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.

Authors:  Radu Huculeci; Elisa Cilia; Agatha Lyczek; Lieven Buts; Klaartje Houben; Markus A Seeliger; Nico van Nuland; Tom Lenaerts
Journal:  Structure       Date:  2016-09-29       Impact factor: 5.006
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.