BACKGROUND: Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse. METHODS: The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). RESULTS: Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk. CONCLUSIONS: These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population. IMPACT: Modification of these lifestyle choices may reduce the incidence of gastric cancer. (c)2010 AACR.
BACKGROUND: Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse. METHODS: The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). RESULTS: Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk. CONCLUSIONS: These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population. IMPACT: Modification of these lifestyle choices may reduce the incidence of gastric cancer. (c)2010 AACR.
Authors: Kristin A Moy; Jian-Min Yuan; Fung-Lung Chung; Xue-Li Wang; David Van Den Berg; Renwei Wang; Yu-Tang Gao; Mimi C Yu Journal: Int J Cancer Date: 2009-12-01 Impact factor: 7.396
Authors: N Y Sung; K S Choi; E C Park; K Park; S Y Lee; A K Lee; I J Choi; K W Jung; Y J Won; H R Shin Journal: Br J Cancer Date: 2007-07-17 Impact factor: 7.640
Authors: Julia Butt; Matthew G Varga; Tianyi Wang; Shoichiro Tsugane; Taichi Shimazu; Wei Zheng; Christian C Abnet; Keun-Young Yoo; Sue K Park; Jeongseon Kim; Sun Ha Jee; You-Lin Qiao; Xiao-Ou Shu; Tim Waterboer; Michael Pawlita; Meira Epplein Journal: Cancer Prev Res (Phila) Date: 2019-07-26