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Literature DB >> 20698035

Gastroesophageal reflux disease: From pathophysiology to treatment.

Abstract

This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett's esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.

Entities: Disease

Mesh：

Year: 2010 PMID： 20698035 PMCID： PMC2921084 DOI： 10.3748/wjg.v16.i30.3745

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

52 in total

1. Gastro-oesophageal reflux disease: a decade of changes.

Authors: Marco G Patti; Silvana Perretta
Journal: Asian J Surg Date: 2003-01 Impact factor: 2.767

2. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.

Authors: Douglas A Corley; Ai Kubo; Wei Zhao; Charles Quesenberry
Journal: Gastroenterology Date: 2010-03-27 Impact factor: 22.682

3. Esophageal dysmotility and gastroesophageal reflux disease.

Authors: U Diener; M G Patti; D Molena; P M Fisichella; L W Way
Journal: J Gastrointest Surg Date: 2001 May-Jun Impact factor: 3.452

Review 4. Brazilian consensus on gastroesophageal reflux disease: proposals for assessment, classification, and management.

Authors: JoaquimPradoP Moraes-Filho; Ivan Cecconello; Joaquim Gama-Rodrigues; LuizdePaula Castro; Maria Aparecida Henry; Ulisses G Meneghelli; Eamonn Quigley
Journal: Am J Gastroenterol Date: 2002-02 Impact factor: 10.864

Review 5. Helicobacter pylori and gastroesophageal reflux disease.

Authors: D C Metz; J A Kroser
Journal: Gastroenterol Clin North Am Date: 1999-12 Impact factor: 3.806

6. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH.

Authors: M F Vela; R Tutuian; P O Katz; D O Castell
Journal: Aliment Pharmacol Ther Date: 2003-01 Impact factor: 8.171

7. Relationship between body mass and gastro-oesophageal reflux symptoms: The Bristol Helicobacter Project.

Authors: Liam Murray; Brian Johnston; Athene Lane; Ian Harvey; Jenny Donovan; Prakash Nair; Richard Harvey
Journal: Int J Epidemiol Date: 2003-08 Impact factor: 7.196

8. Total fundoplication is superior to partial fundoplication even when esophageal peristalsis is weak.

Authors: Marco G Patti; Thomas Robinson; Carlos Galvani; Maria V Gorodner; Piero M Fisichella; Lawrence W Way
Journal: J Am Coll Surg Date: 2004-06 Impact factor: 6.113

Review 9. Radionuclide gastroesophageal motor studies.

Authors: Giuliano Mariani; Giuseppe Boni; Marco Barreca; Massimo Bellini; Bruno Fattori; Abedallatif AlSharif; Mariano Grosso; Cristina Stasi; Francesco Costa; Marco Anselmino; Santino Marchi; Domenico Rubello; H William Strauss
Journal: J Nucl Med Date: 2004-06 Impact factor: 10.057

10. Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett's esophagus: acid reflux, bile reflux, or both?

Authors: J Tack; G Koek; I Demedts; D Sifrim; J Janssens
Journal: Am J Gastroenterol Date: 2004-06 Impact factor: 10.864

31 in total

1. Pathophysiology of Gastroesophageal Reflux in Patients with Chronic Pulmonary Obstructive Disease Is Linked to an Increased Transdiaphragmatic Pressure Gradient and not to a Defective Esophagogastric Barrier.

Authors: Leonardo M Del Grande; Fernando A M Herbella; Amilcar M Bigatao; Henrique Abrao; Jose R Jardim; Marco G Patti
Journal: J Gastrointest Surg Date: 2015-09-24 Impact factor: 3.452

2. Inhaled Beta Agonist Bronchodilator Does Not Affect Trans-diaphragmatic Pressure Gradient but Decreases Lower Esophageal Sphincter Retention Pressure in Patients with Chronic Obstructive Pulmonary Disease (COPD) and Gastroesophageal Reflux Disease (GERD).

Authors: Leonardo M Del Grande; Fernando A M Herbella; Amilcar M Bigatao; Jose R Jardim; Marco G Patti
Journal: J Gastrointest Surg Date: 2016-06-27 Impact factor: 3.452

3. Effects of refluxate pH values on duodenogastroesophageal reflux-induced esophageal adenocarcinoma.

Authors: Peng Cheng; Jian-Sheng Li; Jun Gong; Lian-Feng Zhang; Rong-Zhong Chen
Journal: World J Gastroenterol Date: 2011-07-07 Impact factor: 5.742

Review 4. Pathophysiology of gastroesophageal reflux disease: how an antireflux procedure works (or does not work).

Authors: Fernando A M Herbella; Francisco Schlottmann; Marco G Patti
Journal: Updates Surg Date: 2018-07-23

5. Prevalence of virulent Helicobacter pylori strains in patients affected by idiopathic dysrhythmias.

Authors: Francesco Franceschi; Donatella Brisinda; Francesco Buccelletti; Maria Pia Ruggieri; Antonio Gasbarrini; Annarita Sorbo; Davide Marsiliani; Angela Venuti; Peter Fenici; Giovanni Gasbarrini; Nicolò Gentiloni Silveri; Riccardo Fenici
Journal: Intern Emerg Med Date: 2011-05-12 Impact factor: 3.397