BACKGROUND: Most non-Hodgkin lymphoma (NHL) subtypes occur more among men than women. Since sex hormones may influence immune function, female hormones may be involved. To investigate the relationship between NHL subtypes and reproductive factors, findings from a UK population-based case-control study (1998-2003) are presented. METHODS: Female cases (n = 389) and controls (n = 394) aged 16-69 reported their reproductive histories. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using unconditional logistic regression. RESULTS: No associations were found for age at menarche, parity, or age at first child. Among postmenopausal women, hormone therapy (HT) users had risks of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) below one compared to non-users (OR = 0.7, 95% CI 0.5,1.2; OR = 0.6, 95% CI 0.4,1.0, respectively). Estimates agree with other reports: meta-analyses gave pooled ORs of 0.8 (95% CI 0.6,0.9) for DLBCL and 1.0 (95% CI 0.8,1.2) for FL. In our study, ORs decreased with years of HT use: less and more than 5 years being 0.9 (95% CI 0.5,1.5) and 0.6 (95% CI 0.3,1.1) for DLBCL (p-trend = 0.22), and 0.8 (95% CI 0.4,1.4) and 0.4 (95% CI 0.2,0.9) for FL (p-trend = 0.06). CONCLUSION: For greater power to investigate the association of hormones with DLBCL, FL, and rarer NHL subtypes, pooling data through the International Lymphoma Epidemiology Consortium (InterLymph) is warranted.
BACKGROUND: Most non-Hodgkin lymphoma (NHL) subtypes occur more among men than women. Since sex hormones may influence immune function, female hormones may be involved. To investigate the relationship between NHL subtypes and reproductive factors, findings from a UK population-based case-control study (1998-2003) are presented. METHODS: Female cases (n = 389) and controls (n = 394) aged 16-69 reported their reproductive histories. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using unconditional logistic regression. RESULTS: No associations were found for age at menarche, parity, or age at first child. Among postmenopausal women, hormone therapy (HT) users had risks of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) below one compared to non-users (OR = 0.7, 95% CI 0.5,1.2; OR = 0.6, 95% CI 0.4,1.0, respectively). Estimates agree with other reports: meta-analyses gave pooled ORs of 0.8 (95% CI 0.6,0.9) for DLBCL and 1.0 (95% CI 0.8,1.2) for FL. In our study, ORs decreased with years of HT use: less and more than 5 years being 0.9 (95% CI 0.5,1.5) and 0.6 (95% CI 0.3,1.1) for DLBCL (p-trend = 0.22), and 0.8 (95% CI 0.4,1.4) and 0.4 (95% CI 0.2,0.9) for FL (p-trend = 0.06). CONCLUSION: For greater power to investigate the association of hormones with DLBCL, FL, and rarer NHL subtypes, pooling data through the International Lymphoma Epidemiology Consortium (InterLymph) is warranted.
Authors: Laura Costas; Leila Lujan-Barroso; Yolanda Benavente; Naomi E Allen; Pilar Amiano; Eva Ardanaz; Caroline Besson; Heiner Boeing; Bas Bueno-de-Mesquita; Iris Cervenka; Renée T Fortner; Agnès Fournier; Marc Gunter; Sophia Harlid; José María Huerta; Mats Jerkeman; Karin Jirström; Rudolf Kaaks; Anna Karakatsani; Kay-Tee Khaw; Anastasia Kotanidou; Eiliv Lund; Giovanna Masala; Amalia Mattiello; Beatrice Melin; Virginia Menéndez; Neil Murphy; Alexandra Nieters; Kim Overvad; Elio Riboli; Carlotta Sacerdote; Maria-Jose Sánchez; Julie A Schmidt; Sabina Sieri; Anne Tjønneland; Antonia Trichopoulou; Rosario Tumino; Roel Vermeulen; Elisabete Weiderpass; Silvia de Sanjosé; Antonio Agudo; Delphine Casabonne Journal: Am J Epidemiol Date: 2019-02-01 Impact factor: 4.897
Authors: E V Kane; L Bernstein; P M Bracci; J R Cerhan; L Costas; L Dal Maso; E A Holly; C La Vecchia; K Matsuo; S Sanjose; J J Spinelli; S S Wang; Y Zhang; T Zheng; E Roman; A Kricker Journal: Ann Oncol Date: 2012-09-11 Impact factor: 32.976
Authors: Alexis D Leal; Carrie A Thompson; Alice H Wang; Robert A Vierkant; Thomas M Habermann; Julie A Ross; Ruben A Mesa; Beth A Virnig; James R Cerhan Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-11-12 Impact factor: 4.254
Authors: Kerstin Weitmann; Carsten Hirt; Sabine Schwarz; Charles Rabkin; Gottfried Dölken; Wolfgang Hoffmann Journal: Cancer Causes Control Date: 2015-01-30 Impact factor: 2.506