E V Kane1, L Bernstein2, P M Bracci3, J R Cerhan4, L Costas5, L Dal Maso6, E A Holly3, C La Vecchia7, K Matsuo8, S Sanjose5, J J Spinelli9, S S Wang2, Y Zhang10, T Zheng10, E Roman11, A Kricker12. 1. Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK. Electronic address: eleanor.kane@egu.york.ac.uk. 2. Department of Population Sciences, Division of Cancer Etiology, City of Hope National Medical Center, Duarte. 3. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco. 4. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA. 5. Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, CIBERESP, Catalan Institute of Oncology, Barcelona, Spain. 6. Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano. 7. Department of Occupational Medicine, Istituto di Ricerche Farmacologiche 'Mario Negri', Universitá degli Studi di Milano, Milan, Italy. 8. Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan. 9. Cancer Control Research, BC Cancer Agency Research Center, Vancouver, British Columbia, Canada. 10. School of Public Health, Yale University, New Haven, USA. 11. Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK. 12. Sydney School of Public Health, The University of Sydney, Sydney, Australia.
Abstract
BACKGROUND: Non-Hodgkin lymphoma (NHL) subtypes, diffuse large B-cell (DLBCL) and follicular lymphoma (FL) have different sex ratios and are diagnosed at ages over 60 years; DLBCL is more common in men and diagnosed at older ages than FL, which occurs more among women. This analysis of postmenopausal women examines the relationship between postmenopausal hormone therapy and NHL. DESIGN: Self-reported use of postmenopausal hormone therapy from 2094 postmenopausal women with NHL and 2731 without were pooled across nine case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odds ratios (OR) and 95% confidence intervals (CI) estimated using logistic regression were pooled using random-effects meta-analyses. RESULTS: Postmenopausal women who used hormone therapy were at decreased risk of NHL (pooled OR = 0.79, 95% CI 0.69-0.90). Risks were reduced when the age of starting was 50 years or older. There was no clear trend with number of years of use. Current users were at decreased risk while those stopping over 2 years before diagnosis were not. Having a hysterectomy or not did not affect the risk. Favourable effects were present for DLBCL (pooled OR = 0.66, 95% CI 0.54-0.80) and FL (pooled OR = 0.82, 95% CI 0.66-1.01). CONCLUSION: Postmenopausal hormone therapy, particularly used close to menopause, is associated with a decreased risk of NHL.
BACKGROUND:Non-Hodgkin lymphoma (NHL) subtypes, diffuse large B-cell (DLBCL) and follicular lymphoma (FL) have different sex ratios and are diagnosed at ages over 60 years; DLBCL is more common in men and diagnosed at older ages than FL, which occurs more among women. This analysis of postmenopausal women examines the relationship between postmenopausal hormone therapy and NHL. DESIGN: Self-reported use of postmenopausal hormone therapy from 2094 postmenopausal women with NHL and 2731 without were pooled across nine case-control studies (1983-2005) from North America, Europe and Japan. Study-specific odds ratios (OR) and 95% confidence intervals (CI) estimated using logistic regression were pooled using random-effects meta-analyses. RESULTS: Postmenopausal women who used hormone therapy were at decreased risk of NHL (pooled OR = 0.79, 95% CI 0.69-0.90). Risks were reduced when the age of starting was 50 years or older. There was no clear trend with number of years of use. Current users were at decreased risk while those stopping over 2 years before diagnosis were not. Having a hysterectomy or not did not affect the risk. Favourable effects were present for DLBCL (pooled OR = 0.66, 95% CI 0.54-0.80) and FL (pooled OR = 0.82, 95% CI 0.66-1.01). CONCLUSION: Postmenopausal hormone therapy, particularly used close to menopause, is associated with a decreased risk of NHL.
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