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Literature DB >> 20697207

Evolution of CST function in telomere maintenance.

Carolyn M Price¹, Kara A Boltz, Mary F Chaiken, Jason A Stewart, Mark A Beilstein, Dorothy E Shippen.

Abstract

Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.

Entities: Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20697207 PMCID： PMC3041159 DOI： 10.4161/cc.9.16.12547

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

55 in total

1. The mechanism of action of an accessory protein for DNA polymerase alpha/primase.

Authors: M Goulian; C J Heard
Journal: J Biol Chem Date: 1990-08-05 Impact factor: 5.157

2. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

Authors: N Grandin; S I Reed; M Charbonneau
Journal: Genes Dev Date: 1997-02-15 Impact factor: 11.361

3. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.

Authors: N Grandin; C Damon; M Charbonneau
Journal: EMBO J Date: 2001-03-01 Impact factor: 11.598

4. Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme.

Authors: Bosun Min; Kathleen Collins
Journal: J Biol Chem Date: 2010-04-02 Impact factor: 5.157

5. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.

Authors: H Qi; V A Zakian
Journal: Genes Dev Date: 2000-07-15 Impact factor: 11.361

6. Purification and properties of an accessory protein for DNA polymerase alpha/primase.

Authors: M Goulian; C J Heard; S L Grimm
Journal: J Biol Chem Date: 1990-08-05 Impact factor: 5.157

7. Conserved structure for single-stranded telomeric DNA recognition.

Authors: Rachel M Mitton-Fry; Emily M Anderson; Timothy R Hughes; Victoria Lundblad; Deborah S Wuttke
Journal: Science Date: 2002-04-05 Impact factor: 47.728

8. Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens.

Authors: Eugene V Shakirov; Pierre-François Perroud; Andrew D Nelson; Maren E Cannell; Ralph S Quatrano; Dorothy E Shippen
Journal: Plant Cell Date: 2010-06-01 Impact factor: 11.277

9. Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.

Authors: Simona Grossi; Andrea Puglisi; Petr V Dmitriev; Massimo Lopes; David Shore
Journal: Genes Dev Date: 2004-05-01 Impact factor: 11.361

10. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint.

Authors: B Garvik; M Carson; L Hartwell
Journal: Mol Cell Biol Date: 1995-11 Impact factor: 4.272

100 in total

1. Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job.

Authors: Mary-Lou Pardue; Pg Debaryshe
Journal: Mob Genet Elements Date: 2011-07-01

2. Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus.

Authors: Beverley H Anderson; Paul R Kasher; Josephine Mayer; Marcin Szynkiewicz; Emma M Jenkinson; Sanjeev S Bhaskar; Jill E Urquhart; Sarah B Daly; Jonathan E Dickerson; James O'Sullivan; Elisabeth Oppliger Leibundgut; Joanne Muter; Ghada M H Abdel-Salem; Riyana Babul-Hirji; Peter Baxter; Andrea Berger; Luisa Bonafé; Janice E Brunstom-Hernandez; Johannes A Buckard; David Chitayat; Wui K Chong; Duccio M Cordelli; Patrick Ferreira; Joel Fluss; Ewan H Forrest; Emilio Franzoni; Caterina Garone; Simon R Hammans; Gunnar Houge; Imelda Hughes; Sebastien Jacquemont; Pierre-Yves Jeannet; Rosalind J Jefferson; Ram Kumar; Georg Kutschke; Staffan Lundberg; Charles M Lourenço; Ramesh Mehta; Sakkubai Naidu; Ken K Nischal; Luís Nunes; Katrin Ounap; Michel Philippart; Prab Prabhakar; Sarah R Risen; Raphael Schiffmann; Calvin Soh; John B P Stephenson; Helen Stewart; Jon Stone; John L Tolmie; Marjo S van der Knaap; Jose P Vieira; Catheline N Vilain; Emma L Wakeling; Vanessa Wermenbol; Andrea Whitney; Simon C Lovell; Stefan Meyer; John H Livingston; Gabriela M Baerlocher; Graeme C M Black; Gillian I Rice; Yanick J Crow
Journal: Nat Genet Date: 2012-01-22 Impact factor: 38.330

3. Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.

Authors: Jianing Xu; Michael J McEachern
Journal: Mol Cell Biol Date: 2012-05-29 Impact factor: 4.272

4. Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening.

Authors: Tracy T Chow; Yong Zhao; Sabrina S Mak; Jerry W Shay; Woodring E Wright
Journal: Genes Dev Date: 2012-06-01 Impact factor: 11.361

Review 5. Structural anatomy of telomere OB proteins.

Authors: Martin P Horvath
Journal: Crit Rev Biochem Mol Biol Date: 2011-10 Impact factor: 8.250

6. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.

Authors: Jiansen Jiang; Henry Chan; Darian D Cash; Edward J Miracco; Rachel R Ogorzalek Loo; Heather E Upton; Duilio Cascio; Reid O'Brien Johnson; Kathleen Collins; Joseph A Loo; Z Hong Zhou; Juli Feigon
Journal: Science Date: 2015-10-15 Impact factor: 47.728