Literature DB >> 20696871

Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS.

Jun-Ren Sun1, Ming-Chin Chan, Tein-Yao Chang, Wei-Yao Wang, Tzong-Shi Chiueh.   

Abstract

Thirteen clinical isolates of multidrug-resistant Acinetobacter baumannii resistant to carbapenems (MRAB-C) with tigecycline nonsusceptibility were collected from individual patients in this study. None of the 13 isolates shared the same strain characteristics in molecular typing. All of them showed increased adeB transcription, as predicted. However, none of these tigecycline-nonsusceptible MRAB-C isolates were found to possess previously known adeRS mutations. Upregulation of adeB transcription may result from cross stimulation by other mechanisms.

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Year:  2010        PMID： 20696871      PMCID： PMC2976115          DOI： 10.1128/AAC.00414-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.

Authors:  S Magnet; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections.

Authors:  S A Van Wart; J S Owen; E A Ludwig; A K Meagher; J M Korth-Bradley; B B Cirincione
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

3.  Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region.

Authors:  Hsien Chang Chang; Yu Fang Wei; Lenie Dijkshoorn; Mario Vaneechoutte; Chung Tao Tang; Tsung Chain Chang
Journal:  J Clin Microbiol       Date:  2005-04       Impact factor: 5.948

4.  Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii.

Authors:  Harald Seifert; Lucilla Dolzani; Raffaela Bressan; Tanny van der Reijden; Beppie van Strijen; Danuta Stefanik; Herre Heersma; Lenie Dijkshoorn
Journal:  J Clin Microbiol       Date:  2005-09       Impact factor: 5.948

5.  In vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in Taiwan.

Authors:  Nai-Cheng Cheng; Po-Ren Hsueh; Yung-Ching Liu; Jainn-Ming Shyr; Wen-Kuei Huang; Lee-Jene Teng; Cheng-Yi Liu
Journal:  Microb Drug Resist       Date:  2005       Impact factor: 3.431

6.  Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.

Authors:  Neil Woodford; Matthew J Ellington; Juliana M Coelho; Jane F Turton; M Elaina Ward; Susan Brown; Sebastian G B Amyes; David M Livermore
Journal:  Int J Antimicrob Agents       Date:  2006-03-24       Impact factor: 5.283

Review 7.  Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.

Authors:  F C Tenover; R D Arbeit; R V Goering; P A Mickelsen; B E Murray; D H Persing; B Swaminathan
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948

8.  Identification of epidemic strains of Acinetobacter baumannii by integrase gene PCR.

Authors:  J G Koeleman; J Stoof; M W Van Der Bijl; C M Vandenbroucke-Grauls; P H Savelkoul
Journal:  J Clin Microbiol       Date:  2001-01       Impact factor: 5.948

9.  In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria.

Authors:  M L van Ogtrop; D Andes; T J Stamstad; B Conklin; W J Weiss; W A Craig; O Vesga
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

10.  Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system.

Authors:  Isabelle Marchand; Laurence Damier-Piolle; Patrice Courvalin; Thierry Lambert
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191
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  18 in total

1.  First Occurrence of OXA-72-Producing Acinetobacter baumannii in Serbia.

Authors:  Laurent Dortet; Rémy A Bonnin; Sandrine Bernabeu; Lélia Escaut; Daniel Vittecoq; Delphine Girlich; Dilek Imanci; Nicolas Fortineau; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Genetic Variability of AdeRS Two-Component System Associated with Tigecycline Resistance in XDR-Acinetobacter baumannii Isolates.

Authors:  S Montaña; E Vilacoba; G M Traglia; M Almuzara; M Pennini; A Fernández; A Sucari; D Centrón; M S Ramírez
Journal:  Curr Microbiol       Date:  2015-05-05       Impact factor: 2.188

3.  Phenotype microarray analysis of the AdeRS two-component system in Acinetobacter baumannii.

Authors:  J-R Sun; Y-S Chiang; H-S Shang; C-L Perng; Y-S Yang; T-S Chiueh
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-07-24       Impact factor: 3.267

Review 4.  Antimicrobial resistance in Acinetobacter baumannii: From bench to bedside.

Authors:  Ming-Feng Lin; Chung-Yu Lan
Journal:  World J Clin Cases       Date:  2014-12-16       Impact factor: 1.337

5.  IS5 element integration, a novel mechanism for rapid in vivo emergence of tigecycline nonsusceptibility in Klebsiella pneumoniae.

Authors:  Lindsey E Nielsen; Erik C Snesrud; Fatma Onmus-Leone; Yoon I Kwak; Ricardo Avilés; Eric D Steele; Deena E Sutter; Paige E Waterman; Emil P Lesho
Journal:  Antimicrob Agents Chemother       Date:  2014-08-04       Impact factor: 5.191

6.  RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.

Authors:  Eun-Jeong Yoon; Patrice Courvalin; Catherine Grillot-Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2013-04-15       Impact factor: 5.191

7.  AdeRS combination codes differentiate the response to efflux pump inhibitors in tigecycline-resistant isolates of extensively drug-resistant Acinetobacter baumannii.

Authors:  J-R Sun; C-L Perng; J-C Lin; Y-S Yang; M-C Chan; T-Y Chang; F-M Lin; T-S Chiueh
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-06-18       Impact factor: 3.267

8.  A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism.

Authors:  Vincent Trebosc; Sarah Gartenmann; Kevin Royet; Pablo Manfredi; Marcus Tötzl; Birgit Schellhorn; Michel Pieren; Marcel Tigges; Sergio Lociuro; Peter C Sennhenn; Marc Gitzinger; Dirk Bumann; Christian Kemmer
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

9.  Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.

Authors:  C Rumbo; E Gato; M López; C Ruiz de Alegría; F Fernández-Cuenca; L Martínez-Martínez; J Vila; J Pachón; J M Cisneros; J Rodríguez-Baño; A Pascual; G Bou; M Tomás
Journal:  Antimicrob Agents Chemother       Date:  2013-08-12       Impact factor: 5.191

10.  Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital.

Authors:  Mei Deng; Man-Hua Zhu; Jun-Jie Li; Sheng Bi; Zi-Ke Sheng; Fei-Shu Hu; Jia-Jie Zhang; Wei Chen; Xiao-Wei Xue; Ji-Fang Sheng; Lan-Juan Li
Journal:  Antimicrob Agents Chemother       Date:  2013-10-28       Impact factor: 5.191
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