Literature DB >> 20695453

Efficient syntheses of thiadiazole peptides.

Alan R Katritzky1, Claudia El-Nachef, Kiran Bajaj, Jonathan Kubik, Danniebelle N Haase.   

Abstract

Novel N-(Cbz-aminoacyl)thiosemicarbazides 3a-c were cyclized by treatment with sulfuric acid to give 1,3,4-thiadiazoles 4a-c. Compounds 4a-c reacted with N-(Cbz-aminoacyl)- and -dipeptidoylbenzotriazoles to afford chirally pure 1,3,4-thiadiazol-2-yl-substituted amino acids 6a-c and dipeptides 7a-c.

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Year:  2010        PMID： 20695453     DOI： 10.1021/jo100922c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Straightforward synthesis of various chiral pyrimidines bearing a stereogenic center adjacent to the C-2 position, including C-terminal peptide isosteres.

Authors:  Sami Sahtel; Chayma Ben Maamer; Rafâa Besbes; Emmanuel Vrancken; Jean-Marc Campagne
Journal:  Amino Acids       Date:  2022-10-13       Impact factor: 3.789

2.  Bis(2-amino-5-methyl-1,3,4-thia-diazole-κN(3))dichloridocobalt(II).

Authors:  Ye Song; Yu-Fei Ji; Min-Yan Kang; Zhi-Liang Liu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-16

3.  Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid-sulphonamide conjugates.

Authors:  Hasan Küçükbay; Nesrin Buğday; F Zehra Küçükbay; Andrea Ageli; Gianluca Bartolucci; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  3 in total

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