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Literature DB >> 20694488

Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia.

Chen Zhang¹, Bin Xie, Yasong Du, Wenhong Cheng, Yiru Fang, Shunying Yu.

Abstract

Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08-1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2010 PMID： 20694488 DOI： 10.1007/s00702-010-0442-3

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

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