Literature DB >> 20692832

Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.

Laetitia Mony1, Nicolas Triballeau, Pierre Paoletti, Francine C Acher, Hugues-Olivier Bertrand.   

Abstract

We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20692832     DOI： 10.1016/j.bmcl.2010.07.043

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

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Journal:  Pharmaceutics       Date:  2011-12-09       Impact factor: 6.321
  3 in total

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