Literature DB >> 20692195

Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster.

Helene Verhelst1, Patrick Verloo, Karlien Dhondt, Boel De Paepe, Björn Menten, Josep Dalmau, Rudy Van Coster.   

Abstract

Anti-NMDA-receptor encephalitis was initially described as a paraneoplastic disorder in young women with ovarian teratoma. We report on a 3-year-old boy who developed anti-NMDA-receptor encephalitis one month after a respiratory infection. Moreover, array-comparative genomic hybridization in this patient revealed an inherited microdeletion in chromosomeband 6p21.32, including the HLA-DPB1 and HLA-DPB2 genes. The clinical relevance of this microdeletion is discussed.
Copyright © 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20692195      PMCID： PMC3086678          DOI： 10.1016/j.ejpn.2010.07.004

Source DB:  PubMed          Journal:  Eur J Paediatr Neurol        ISSN： 1090-3798            Impact factor:   3.140


  9 in total

1.  Genomic HLA profiles of MS in Hokkaido, Japan: important role of DPB1*0501 allele.

Authors:  T Fukazawa; S Kikuchi; H Sasaki; I Yabe; R Miyagishi; T Hamada; K Tashiro
Journal:  J Neurol       Date:  2000-03       Impact factor: 4.849

2.  HLA-DPB polymorphisms: Glu 69 association with sarcoidosis.

Authors:  P A Lympany; M Petrek; A M Southcott; A J Newman Taylor; K I Welsh; R M du Bois
Journal:  Eur J Immunogenet       Date:  1996-10

3.  HLA-DPB1*0202 is associated with a predictor of good prognosis of Graves' disease in the Japanese.

Authors:  Megumi Takahashi; Michio Yasunami; Sumihisa Kubota; Hajime Tamai; Akinori Kimura
Journal:  Hum Immunol       Date:  2006-04-03       Impact factor: 2.850

4.  Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.

Authors:  Josep Dalmau; Erdem Tüzün; Hai-yan Wu; Jaime Masjuan; Jeffrey E Rossi; Alfredo Voloschin; Joachim M Baehring; Haruo Shimazaki; Reiji Koide; Dale King; Warren Mason; Lauren H Sansing; Marc A Dichter; Myrna R Rosenfeld; David R Lynch
Journal:  Ann Neurol       Date:  2007-01       Impact factor: 10.422

5.  Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study.

Authors:  Takahiro Iizuka; Shintaro Yoshii; Shinichi Kan; Junichi Hamada; Josep Dalmau; Fumihiko Sakai; Hideki Mochizuki
Journal:  J Neurol       Date:  2010-06-02       Impact factor: 4.849

6.  Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.

Authors:  Josep Dalmau; Amy J Gleichman; Ethan G Hughes; Jeffrey E Rossi; Xiaoyu Peng; Meizan Lai; Scott K Dessain; Myrna R Rosenfeld; Rita Balice-Gordon; David R Lynch
Journal:  Lancet Neurol       Date:  2008-10-11       Impact factor: 44.182

7.  Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents.

Authors:  Nicole R Florance; Rebecca L Davis; Christopher Lam; Christina Szperka; Lei Zhou; Saba Ahmad; Cynthia J Campen; Heather Moss; Nadja Peter; Amy J Gleichman; Carol A Glaser; David R Lynch; Myrna R Rosenfeld; Josep Dalmau
Journal:  Ann Neurol       Date:  2009-07       Impact factor: 10.422

Review 8.  HLA class II and autoimmunity: epitope selection vs differential expression.

Authors:  Brigitte Müller-Hilke
Journal:  Acta Histochem       Date:  2008-12-31       Impact factor: 2.479

9.  HLA-DPB1 polymorphisms in patients with hyperthyroid Graves' disease and early onset myasthenia gravis.

Authors:  S Ratanachaiyavong; D Fleming; M Janer; A G Demaine; N Willcox; J Newsom-Davis; A M McGregor
Journal:  Autoimmunity       Date:  1994       Impact factor: 2.815
  9 in total
  8 in total

Review 1.  Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis.

Authors:  Josep Dalmau; Eric Lancaster; Eugenia Martinez-Hernandez; Myrna R Rosenfeld; Rita Balice-Gordon
Journal:  Lancet Neurol       Date:  2011-01       Impact factor: 44.182

2.  Anti-NMDAR encephalitis: a new, severe and challenging enduring entity.

Authors:  Emma H C W van de Riet; Maite M Esseveld; Leen Cuypers; Jan N M Schieveld
Journal:  Eur Child Adolesc Psychiatry       Date:  2012-12-19       Impact factor: 4.785

Review 3.  Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.

Authors:  Mia Levite
Journal:  J Neural Transm (Vienna)       Date:  2014-08-01       Impact factor: 3.575

4.  Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.

Authors:  Nicolas Greliche; Tanja Zeller; Philipp S Wild; Maxime Rotival; Arne Schillert; Andreas Ziegler; Panos Deloukas; Jeanette Erdmann; Christian Hengstenberg; Willem H Ouwehand; Nilesh J Samani; Heribert Schunkert; Thomas Munzel; Karl J Lackner; François Cambien; Alison H Goodall; Laurence Tiret; Stefan Blankenberg; David-Alexandre Trégouët
Journal:  PLoS One       Date:  2012-09-21       Impact factor: 3.240

Review 5.  Pediatric Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Review with Pooled Analysis and Critical Care Emphasis.

Authors:  Kenneth E Remy; Jason W Custer; Joshua Cappell; Cortney B Foster; Nan A Garber; L Kyle Walker; Liliana Simon; Dayanand Bagdure
Journal:  Front Pediatr       Date:  2017-11-24       Impact factor: 3.418

6.  Teratoma-associated anti-NMDAR encephalitis: Two cases report and literature review.

Authors:  Zhigang Liang; Shaowan Yang; Xuwen Sun; Bing Li; Wei Li; Zhuli Liu; Guoping Yu
Journal:  Medicine (Baltimore)       Date:  2017-12       Impact factor: 1.817

Review 7.  Teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis: A case report and literature review.

Authors:  Bin Yan; You Wang; Ying Zhang; Weihua Lou
Journal:  Medicine (Baltimore)       Date:  2019-05       Impact factor: 1.817

8.  Anti-N-methyl-d-aspartate receptor encephalitis in Korea: clinical features, treatment, and outcome.

Authors:  Jung-Ah Lim; Soon-Tae Lee; Keun-Hwa Jung; Soyun Kim; Jung-Won Shin; Jangsup Moon; Jung-Ick Byun; Tae-Joon Kim; Yong-Won Shin; Keon-Joo Lee; Young-Su Kim; Kyung-Il Park; Sang Kun Lee; Kon Chu
Journal:  J Clin Neurol       Date:  2014-04-23       Impact factor: 3.077
  8 in total

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