OBJECTIVE: To determine the frequency of chronic obstructive pulmonary disease (COPD) as a sequel of treated pulmonary tuberculosis. STUDY DESIGN: A case series. PLACE AND DURATION OF STUDY: Department of Pulmonology, Military Hospital, Rawalpindi, from April to November 2007. METHODOLOGY: Forty seven adults, previously treated for pulmonary tuberculosis and presenting subsequently with chronic exertional dyspnoea for which no other alternate cause was found were included. Those having a probability of re-activated TB, having history of current or previous smoking or occupational exposure, asthmatics and cases of interstitial lung disease and ischemic heart disease were excluded. Pre- and post-dilator FVC, FEV1 and FEV1/FVC were recorded in each case through simple spirometry on Spirolab-II-MIR S/N 507213. Stage and pattern of COPD was recorded. RESULTS: There were 76.5% (n=36) males. Mean age was 56.4 and 44.2 years in males and females respectively. Twenty six (55.3%) were found to have an obstructive ventilatory defect of different degrees: severe/stage III in 69.2% (n=18), moderate/stage II in 23.0 % (n=6) and mild/stage I in 5.9% (n=2). Fourteen (29.7%) were found to have a restrictive pattern and 7 (14.8%) revealed a mixed obstructive and restrictive pattern. CONCLUSION: Chronic obstructive pulmonary disease can occur as one of the chronic complications of pulmonary tuberculosis and the obstructive ventilatory defect appears more common among various pulmonary function derangements.
OBJECTIVE: To determine the frequency of chronic obstructive pulmonary disease (COPD) as a sequel of treated pulmonary tuberculosis. STUDY DESIGN: A case series. PLACE AND DURATION OF STUDY: Department of Pulmonology, Military Hospital, Rawalpindi, from April to November 2007. METHODOLOGY: Forty seven adults, previously treated for pulmonary tuberculosis and presenting subsequently with chronic exertional dyspnoea for which no other alternate cause was found were included. Those having a probability of re-activated TB, having history of current or previous smoking or occupational exposure, asthmatics and cases of interstitial lung disease and ischemic heart disease were excluded. Pre- and post-dilator FVC, FEV1 and FEV1/FVC were recorded in each case through simple spirometry on Spirolab-II-MIR S/N 507213. Stage and pattern of COPD was recorded. RESULTS: There were 76.5% (n=36) males. Mean age was 56.4 and 44.2 years in males and females respectively. Twenty six (55.3%) were found to have an obstructive ventilatory defect of different degrees: severe/stage III in 69.2% (n=18), moderate/stage II in 23.0 % (n=6) and mild/stage I in 5.9% (n=2). Fourteen (29.7%) were found to have a restrictive pattern and 7 (14.8%) revealed a mixed obstructive and restrictive pattern. CONCLUSION:Chronic obstructive pulmonary disease can occur as one of the chronic complications of pulmonary tuberculosis and the obstructive ventilatory defect appears more common among various pulmonary function derangements.
Authors: André F S Amaral; Sonia Coton; Bernet Kato; Wan C Tan; Michael Studnicka; Christer Janson; Thorarinn Gislason; David Mannino; Eric D Bateman; Sonia Buist; Peter G J Burney Journal: Eur Respir J Date: 2015-06-25 Impact factor: 16.671
Authors: Stephanus T Malherbe; Shubhada Shenai; Katharina Ronacher; Andre G Loxton; Gregory Dolganov; Magdalena Kriel; Tran Van; Ray Y Chen; James Warwick; Laura E Via; Taeksun Song; Myungsun Lee; Gary Schoolnik; Gerard Tromp; David Alland; Clifton E Barry; Jill Winter; Gerhard Walzl; Lance Lucas; Gian van der Spuy; Kim Stanley; Lani Thiart; Bronwyn Smith; Nelita Du Plessis; Caroline G G Beltran; Elizna Maasdorp; Annare Ellmann; Hongjo Choi; Joonsung Joh; Lori E Dodd; Brian Allwood; Coenie Koegelenberg; Morné Vorster; Stephanie Griffith-Richards Journal: Nat Med Date: 2016-09-05 Impact factor: 53.440