John F Aloia1, Ding-Geng Chen, Henian Chen. 1. Bone Mineral Research Center, Winthrop-University Hospital, Mineola, New York 11501, USA. jaloia@winthrop.org
Abstract
CONTEXT: Black women have lower 25-hydroxyvitamin D [25(OH)D] and higher PTH than white women. Recent evidence implicates PTH in adverse cardiovascular outcomes. OBJECTIVE: The objective of the study was to determine whether PTH increases at lower 25(OH)D levels (the threshold) in black compared with white women. DESIGN: Healthy black and white women, aged 20-80 yr were recruited to participate in a cross-sectional study of body-composition in black and white women. Measurement of serum 25(OH)D and PTH were carried out. SETTING: The study was a convenience sample recruited from a community setting. PATIENTS: Healthy black and white women were recruited by advertising and a direct mail campaign in a comparative study of body composition. Age ranged from 20-to 80 yr. There were 148 black and 129 white premenopausal participants and 87 black and 139 white postmenopausal participants. MAIN OUTCOME: The main outcome was to determine whether the threshold for 25(OH)D/PTH differs in black and white women. RESULTS: A threshold of 37 nmol/liter (95% confidence interval 35-40) was found for black and 59 nmol/liter (95% confidence interval 56-63) for white women. These two values were significantly different (P < 0.001). CONCLUSIONS: Black women have an increase in serum PTH at a lower 25(OH)D level than white women. Negative health outcomes of higher PTH should be investigated in black women.
CONTEXT: Black women have lower 25-hydroxyvitamin D [25(OH)D] and higher PTH than white women. Recent evidence implicates PTH in adverse cardiovascular outcomes. OBJECTIVE: The objective of the study was to determine whether PTH increases at lower 25(OH)D levels (the threshold) in black compared with white women. DESIGN: Healthy black and white women, aged 20-80 yr were recruited to participate in a cross-sectional study of body-composition in black and white women. Measurement of serum 25(OH)D and PTH were carried out. SETTING: The study was a convenience sample recruited from a community setting. PATIENTS: Healthy black and white women were recruited by advertising and a direct mail campaign in a comparative study of body composition. Age ranged from 20-to 80 yr. There were 148 black and 129 white premenopausal participants and 87 black and 139 white postmenopausal participants. MAIN OUTCOME: The main outcome was to determine whether the threshold for 25(OH)D/PTH differs in black and white women. RESULTS: A threshold of 37 nmol/liter (95% confidence interval 35-40) was found for black and 59 nmol/liter (95% confidence interval 56-63) for white women. These two values were significantly different (P < 0.001). CONCLUSIONS: Black women have an increase in serum PTH at a lower 25(OH)D level than white women. Negative health outcomes of higher PTH should be investigated in black women.
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