Literature DB >> 20684953

Androgen excess down-regulates connexin43 in a human granulosa cell line.

Cheng-Hsuan Wu1, Jyuer-Ger Yang, Jiann-Jou Yang, Yueh-Min Lin, Hong-Der Tsai, Ching-Yuang Lin, Pao-Lin Kuo.   

Abstract

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20684953     DOI： 10.1016/j.fertnstert.2010.06.077

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  9 in total

1.  Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells.

Authors:  Hsun-Ming Chang; Jung-Chien Cheng; Elizabeth Taylor; Peter C K Leung
Journal:  Mol Hum Reprod       Date:  2014-01-10       Impact factor: 4.025

2.  Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins.

Authors:  Muraly Puttabyatappa; Ashleigh Irwin; Jacob D Martin; Makeda Mesquitta; Almudena Veiga-Lopez; Vasantha Padmanabhan
Journal:  Reprod Sci       Date:  2017-03-16       Impact factor: 3.060

3.  1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells.

Authors:  Ching-Tien Lee; Jiz-Yuh Wang; Kuang-Yi Chou; Ming-I Hsu
Journal:  Reprod Biol Endocrinol       Date:  2014-09-20       Impact factor: 5.211

4.  Effect of testosterone on the Connexin37 of sexual mature mouse cumulus oocyte complex.

Authors:  Yangyang Zhang; Yang Xu; Yanrong Kuai; Sheng Wang; Qing Xue; Jing Shang
Journal:  J Ovarian Res       Date:  2016-11-23       Impact factor: 4.234

Review 5.  Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors.

Authors:  Hsun-Ming Chang; Jie Qiao; Peter C K Leung
Journal:  Hum Reprod Update       Date:  2016-10-26       Impact factor: 15.610

6.  Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review.

Authors:  Datu Agasi Mohd Kamal; Siti Fatimah Ibrahim; Mohd Helmy Mokhtar
Journal:  Bosn J Basic Med Sci       Date:  2020-08-03       Impact factor: 3.363

7.  The reaggregation of normal granulosa-cumulus cells and mouse oocytes with polycystic ovarian syndrome in vitro: An experimental study.

Authors:  Amaneh Moradi; Fatemeh Ghasemian; Farhad Mashayekhi
Journal:  Int J Reprod Biomed       Date:  2021-12-13

Review 8.  Involvement of androgens in ovarian health and disease.

Authors:  M Lebbe; T K Woodruff
Journal:  Mol Hum Reprod       Date:  2013-09-10       Impact factor: 4.025

9.  AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer.

Authors:  Ruibao Chen; Yang Luan; Zhuo Liu; Wen Song; Licheng Wu; Mingchao Li; Jun Yang; Xiaming Liu; Tao Wang; Jihong Liu; Zhangqun Ye
Journal:  Biomed Res Int       Date:  2015-09-28       Impact factor: 3.411
  9 in total

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