Literature DB >> 20683480

An update on regulatory T cells in transplant tolerance and rejection.

Xian Chang Li1, Laurence A Turka.   

Abstract

Several types of T cells with immunosuppressive properties have been identified, but FOXP3(+) regulatory T (T(REG)) cells have emerged as a dominant cell type; they are critically involved in the induction and maintenance of immune tolerance. Manipulation of this cell type for the induction of transplant tolerance including renal transplant tolerance has attracted considerable attention. Studies in this area have demonstrated unexpected complexities, and attempts to translate T(REG) cells towards clinical utility have met with unanticipated difficulties. In this Review, a broad overview is provided on recent progress in the study of T(REG) cells, focusing on challenges, opportunities, and emerging approaches in exploiting T(REG) cells for the induction of transplant tolerance.

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Year:  2010        PMID： 20683480     DOI： 10.1038/nrneph.2010.101

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN： 1759-5061            Impact factor:   28.314


  61 in total

1.  IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

Authors:  M Hara; C I Kingsley; M Niimi; S Read; S E Turvey; A R Bushell; P J Morris; F Powrie; K J Wood
Journal:  J Immunol       Date:  2001-03-15       Impact factor: 5.422

2.  Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression.

Authors:  Z X Zhang; L Yang; K J Young; B DuTemple; L Zhang
Journal:  Nat Med       Date:  2000-07       Impact factor: 53.440

3.  Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

Authors:  Xin Xiao Zheng; Alberto Sánchez-Fueyo; Masayuki Sho; Christoph Domenig; Mohamed H Sayegh; Terry B Strom
Journal:  Immunity       Date:  2003-10       Impact factor: 31.745

4.  CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.

Authors:  Franco R D'Alessio; Kenji Tsushima; Neil R Aggarwal; Erin E West; Matthew H Willett; Martin F Britos; Matthew R Pipeling; Roy G Brower; Rubin M Tuder; John F McDyer; Landon S King
Journal:  J Clin Invest       Date:  2009-09-21       Impact factor: 14.808

5.  NK cells lyse T regulatory cells that expand in response to an intracellular pathogen.

Authors:  Sugata Roy; Peter F Barnes; Ankita Garg; Shiping Wu; David Cosman; Ramakrishna Vankayalapati
Journal:  J Immunol       Date:  2008-02-01       Impact factor: 5.422

Review 6.  Costimulatory pathways in transplantation: challenges and new developments.

Authors:  Xian C Li; David M Rothstein; Mohamed H Sayegh
Journal:  Immunol Rev       Date:  2009-05       Impact factor: 12.988

7.  Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

Authors:  Nan Zhang; Bernd Schröppel; Girdhari Lal; Claudia Jakubzick; Xia Mao; Dan Chen; Na Yin; Rolf Jessberger; Jordi C Ochando; Yaozhong Ding; Jonathan S Bromberg
Journal:  Immunity       Date:  2009-03-20       Impact factor: 31.745

8.  Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Authors:  Sarah E Allan; Sarah Q Crome; Natasha K Crellin; Laura Passerini; Theodore S Steiner; Rosa Bacchetta; Maria G Roncarolo; Megan K Levings
Journal:  Int Immunol       Date:  2007-02-27       Impact factor: 4.823

9.  The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

Authors:  Sarah E Allan; Laura Passerini; Rosa Bacchetta; Natasha Crellin; Minyue Dai; Paul C Orban; Steven F Ziegler; Maria Grazia Roncarolo; Megan K Levings
Journal:  J Clin Invest       Date:  2005-10-06       Impact factor: 14.808

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
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  54 in total

1.  Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.

Authors:  A D Kirk; A Guasch; H Xu; J Cheeseman; S I Mead; A Ghali; A K Mehta; D Wu; H Gebel; R Bray; J Horan; L S Kean; C P Larsen; T C Pearson
Journal:  Am J Transplant       Date:  2014-03-31       Impact factor: 8.086

2.  The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study.

Authors:  Antonella Afeltra; Antonietta Gigante; Domenico Paolo Emanuele Margiotta; Chiara Taffon; Rosario Cianci; Biagio Barbano; Marta Liberatori; Antonio Amoroso; Filippo Rossi Fanelli
Journal:  Intern Emerg Med       Date:  2015-02-27       Impact factor: 3.397

Review 3.  Face allotransplantation and burns: a review.

Authors:  Anna Arno; J P Barret; Rachael A Harrison; Marc G Jeschke
Journal:  J Burn Care Res       Date:  2012 Sep-Oct       Impact factor: 1.845

4.  Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.

Authors:  Chuan Wu; Theresa Thalhamer; Rafael F Franca; Sheng Xiao; Chao Wang; Chie Hotta; Chen Zhu; Mitsuomi Hirashima; Ana C Anderson; Vijay K Kuchroo
Journal:  Immunity       Date:  2014-07-24       Impact factor: 31.745

5.  Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics.

Authors:  Shuqiu Chen; Lei Zhang; Yuanlin Ying; Yixuan Wang; Preston R Arnold; Guangchuan Wang; Junhui Li; R Mark Ghobrial; Wenhao Chen; Xiang Xiao; Xian C Li
Journal:  Am J Transplant       Date:  2020-04-05       Impact factor: 8.086

6.  Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice.

Authors:  Susanna Choi; Hang-Rae Kim; Lin Leng; Insoo Kang; William L Jorgensen; Chul-Soo Cho; Richard Bucala; Wan-Uk Kim
Journal:  J Immunol       Date:  2012-09-12       Impact factor: 5.422

7.  Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.

Authors:  Emilie Dugast; Endre Kiss-Toth; Louise Docherty; Richard Danger; Mélanie Chesneau; Virginie Pichard; Jean-Paul Judor; Ségolène Pettré; Sophie Conchon; Jean-Paul Soulillou; Sophie Brouard; Joanna Ashton-Chess
Journal:  J Biol Chem       Date:  2013-02-15       Impact factor: 5.157

8.  IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival.

Authors:  Heth R Turnquist; Zhenlin Zhao; Brian R Rosborough; Quan Liu; Antonino Castellaneta; Kumiko Isse; Zhiliang Wang; Megan Lang; Donna Beer Stolz; Xin Xiao Zheng; A Jake Demetris; Foo Y Liew; Kathryn J Wood; Angus W Thomson
Journal:  J Immunol       Date:  2011-09-26       Impact factor: 5.422

9.  Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17.

Authors:  Peter I Lobo; Amandeep Bajwa; Kailo H Schlegel; John Vengal; Sang J Lee; Liping Huang; Hong Ye; Umesh Deshmukh; Tong Wang; Hong Pei; Mark D Okusa
Journal:  J Immunol       Date:  2012-01-18       Impact factor: 5.422

10.  Cyclosporin but not everolimus inhibits chemokine receptor expression on CD4+ T cell subsets circulating in the peripheral blood of renal transplant recipients.

Authors:  A Hoerning; S Köhler; C Jun; J Lu; J Fu; B Tebbe; S Dolff; T Feldkamp; A Kribben; P F Hoyer; O Witzke
Journal:  Clin Exp Immunol       Date:  2012-05       Impact factor: 4.330
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