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Literature DB >> 19303390

Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

Nan Zhang¹, Bernd Schröppel, Girdhari Lal, Claudia Jakubzick, Xia Mao, Dan Chen, Na Yin, Rolf Jessberger, Jordi C Ochando, Yaozhong Ding, Jonathan S Bromberg.

Abstract

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR2, CCR5, and CCR7 fashion; this movement was essential for optimal suppression. Treg cells inhibited dendritic cell migration in a TGF-beta and IL-10 dependent fashion and suppressed antigen-specific T effector cell migration, accumulation, and proliferation in dLNs and allografts. These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19303390 PMCID： PMC2737741 DOI： 10.1016/j.immuni.2008.12.022

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

54 in total

1. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.

Authors: Gudrun F Debes; Carrie N Arnold; Alan J Young; Stefan Krautwald; Martin Lipp; John B Hay; Eugene C Butcher
Journal: Nat Immunol Date: 2005-08-14 Impact factor: 25.606

2. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.

Authors: Shannon K Bromley; Seddon Y Thomas; Andrew D Luster
Journal: Nat Immunol Date: 2005-08-14 Impact factor: 25.606

3. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

Authors: S Jung; J Aliberti; P Graemmel; M J Sunshine; G W Kreutzberg; A Sher; D R Littman
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

4. Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.

Authors: Jordi C Ochando; Adam C Yopp; Yu Yang; Alexandre Garin; Yansui Li; Peter Boros; Jaime Llodra; Yaozhong Ding; Sergio A Lira; Nancy R Krieger; Jonathan S Bromberg
Journal: J Immunol Date: 2005-06-01 Impact factor: 5.422

5. Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

Authors: Jason D Fontenot; Jeffrey P Rasmussen; Luke M Williams; James L Dooley; Andrew G Farr; Alexander Y Rudensky
Journal: Immunity Date: 2005-03 Impact factor: 31.745

6. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.

Authors: A J Wagers; G S Kansas
Journal: J Immunol Date: 2000-11-01 Impact factor: 5.422

7. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.

Authors: M C Huang; O Zöllner; T Moll; P Maly; A D Thall; J B Lowe; D Vestweber
Journal: J Biol Chem Date: 2000-10-06 Impact factor: 5.157

10. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.

Authors: Giorgio Raimondi; Tina L Sumpter; Benjamin M Matta; Mahesh Pillai; Natasha Corbitt; Yoram Vodovotz; Zhiliang Wang; Angus W Thomson
Journal: J Immunol Date: 2009-12-09 Impact factor: 5.422

Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

1. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.

2. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.

3. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

4. Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.

5. Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

6. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.

7. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.

8. Role of donor-derived monocyte chemoattractant protein-1 in murine islet transplantation.

9. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD.

10. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor.

Review 1. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.

Review 2. An update on regulatory T cells in transplant tolerance and rejection.

Review 3. How tolerogenic dendritic cells induce regulatory T cells.

Review 4. Regulatory T cell migration during an immune response.

5. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.

6. BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling.

7. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.

Review 8. Regulatory T cells in nonlymphoid tissues.

Review 9. Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance.

10. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.