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Literature DB >> 20683477

A new nuclease member of the FAN club.

Abstract

To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2010 PMID： 20683477 PMCID： PMC2945811 DOI： 10.1038/nsmb0810-926

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

27 in total

1. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.

Authors: Paul Pace; Georgina Mosedale; Michael R Hodskinson; Ivan V Rosado; Meera Sivasubramaniam; Ketan J Patel
Journal: Science Date: 2010-06-10 Impact factor: 47.728

2. Endonucleolytic function of MutLalpha in human mismatch repair.

Authors: Farid A Kadyrov; Leonid Dzantiev; Nicoleta Constantin; Paul Modrich
Journal: Cell Date: 2006-07-28 Impact factor: 41.582

3. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

Authors: I Garcia-Higuera; T Taniguchi; S Ganesan; M S Meyn; C Timmers; J Hejna; M Grompe; A D D'Andrea
Journal: Mol Cell Date: 2001-02 Impact factor: 17.970

4. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.

Authors: M L Dronkert; J de Wit; M Boeve; M L Vasconcelos; H van Steeg; T L Tan; J H Hoeijmakers; R Kanaar
Journal: Mol Cell Biol Date: 2000-07 Impact factor: 4.272

5. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

Authors: Marzena Bienko; Catherine M Green; Nicola Crosetto; Fabian Rudolf; Grzegorz Zapart; Barry Coull; Patricia Kannouche; Gerhard Wider; Matthias Peter; Alan R Lehmann; Kay Hofmann; Ivan Dikic
Journal: Science Date: 2005-12-16 Impact factor: 47.728

6. Mutation of the RAD51C gene in a Fanconi anemia-like disorder.

Authors: Fiona Vaz; Helmut Hanenberg; Beatrice Schuster; Karen Barker; Constanze Wiek; Verena Erven; Kornelia Neveling; Daniela Endt; Ian Kesterton; Flavia Autore; Franca Fraternali; Marcel Freund; Linda Hartmann; David Grimwade; Roland G Roberts; Heiner Schaal; Shehla Mohammed; Nazneen Rahman; Detlev Schindler; Christopher G Mathew
Journal: Nat Genet Date: 2010-04-18 Impact factor: 38.330

7. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

Authors: Agata Smogorzewska; Rohini Desetty; Takamune T Saito; Michael Schlabach; Francis P Lach; Mathew E Sowa; Alan B Clark; Thomas A Kunkel; J Wade Harper; Monica P Colaiácovo; Stephen J Elledge
Journal: Mol Cell Date: 2010-07-09 Impact factor: 17.970

8. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

Authors: Katja Kratz; Barbara Schöpf; Svenja Kaden; Ataman Sendoel; Ralf Eberhard; Claudio Lademann; Elda Cannavó; Alessandro A Sartori; Michael O Hengartner; Josef Jiricny
Journal: Cell Date: 2010-07-09 Impact factor: 41.582

Review 9. The Fanconi anaemia/BRCA pathway.

Authors: Alan D D'Andrea; Markus Grompe
Journal: Nat Rev Cancer Date: 2003-01 Impact factor: 60.716

10. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

Authors: Craig MacKay; Anne-Cécile Déclais; Cecilia Lundin; Ana Agostinho; Andrew J Deans; Thomas J MacArtney; Kay Hofmann; Anton Gartner; Stephen C West; Thomas Helleday; David M J Lilley; John Rouse
Journal: Cell Date: 2010-07-09 Impact factor: 41.582

20 in total

Review 1. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.

Authors: Hyungjin Kim; Alan D D'Andrea
Journal: Genes Dev Date: 2012-07-01 Impact factor: 11.361

2. Loss of Cohesin Subunit Rec8 Switches Rad51 Mediator Dependence in Resistance to Formaldehyde Toxicity in Ustilago maydis.

Authors: Jeanette H Sutherland; William K Holloman
Journal: Genetics Date: 2018-08-06 Impact factor: 4.562

3. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

Authors: Samuel F Bunting; Elsa Callén; Marina L Kozak; Jung Min Kim; Nancy Wong; Andrés J López-Contreras; Thomas Ludwig; Richard Baer; Robert B Faryabi; Amy Malhowski; Hua-Tang Chen; Oscar Fernandez-Capetillo; Alan D'Andrea; André Nussenzweig
Journal: Mol Cell Date: 2012-03-22 Impact factor: 17.970

Review 4. Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.

Authors: Sharon B Cantor; Shawna Guillemette
Journal: Future Oncol Date: 2011-02 Impact factor: 3.404

5. The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells.

Authors: Ping Chen; Jian Li; Yong-Chang Chen; Hai Qian; Yu-Jiao Chen; Jin-Yu Su; Min Wu; Ting Lan
Journal: Cell Oncol (Dordr) Date: 2016-07-29 Impact factor: 6.730