OBJECTIVE: To re-evaluate the mortality of hypohidrotic ectodermal dysplasia (HED) and the prevalence of hyperpyrexia and possible neurological sequelae in affected infants. STUDY DESIGN: A cross-sectional postal survey was conducted among parents of 100 children with ectodermal dysplasia who had been registered with the German-Swiss-Austrian patient support group at any time point within the past 10 years. Detailed questionnaires referring to the first year of life were evaluated statistically. RESULTS: 63% of parents returned completed surveys, identifying 57% of children as patients with X-linked HED and 20% as patients with autosomal HED or HED of unknown origin. Of those two groups, 17 infants had been placed in an incubator after birth, where body temperature recording proved to be of utmost importance. In 94% of all HED patients, episodes of unexplained fever were observed during the first year of life. X-linked HED was associated with frequent airway infections. Febrile seizures occurred in 5.9% of infants with X-linked HED and in 17% of the other HED patients. Developmental retardation was reported for 15% and 25%, respectively. Prognosis depended on the type of genetic defect and the time point of diagnosis. Except for one all patients survived infancy. Early recognition of the disease was aided by vigilant neonatal care and consulting a dermatologist or geneticist. Adequate instruction of the parents and networking with patient support groups also reduced the risks associated with HED. CONCLUSIONS: Today, mortality of HED and the risk of hyperthermic brain damage are still increased, but lower than reported previously. 2010 Elsevier Ltd. All rights reserved.
OBJECTIVE: To re-evaluate the mortality of hypohidrotic ectodermal dysplasia (HED) and the prevalence of hyperpyrexia and possible neurological sequelae in affected infants. STUDY DESIGN: A cross-sectional postal survey was conducted among parents of 100 children with ectodermal dysplasia who had been registered with the German-Swiss-Austrian patient support group at any time point within the past 10 years. Detailed questionnaires referring to the first year of life were evaluated statistically. RESULTS: 63% of parents returned completed surveys, identifying 57% of children as patients with X-linked HED and 20% as patients with autosomal HED or HED of unknown origin. Of those two groups, 17 infants had been placed in an incubator after birth, where body temperature recording proved to be of utmost importance. In 94% of all HEDpatients, episodes of unexplained fever were observed during the first year of life. X-linked HED was associated with frequent airway infections. Febrile seizures occurred in 5.9% of infants with X-linked HED and in 17% of the other HEDpatients. Developmental retardation was reported for 15% and 25%, respectively. Prognosis depended on the type of genetic defect and the time point of diagnosis. Except for one all patients survived infancy. Early recognition of the disease was aided by vigilant neonatal care and consulting a dermatologist or geneticist. Adequate instruction of the parents and networking with patient support groups also reduced the risks associated with HED. CONCLUSIONS: Today, mortality of HED and the risk of hyperthermic brain damage are still increased, but lower than reported previously. 2010 Elsevier Ltd. All rights reserved.
Authors: Carol A Margolis; Pascal Schneider; Kenneth Huttner; Neil Kirby; Timothy P Houser; Lee Wildman; Gary L Grove; Holm Schneider; Margret L Casal Journal: J Pharmacol Exp Ther Date: 2019-04-18 Impact factor: 4.030
Authors: Kyle B Jones; Alice F Goodwin; Maya Landan; Kerstin Seidel; Dong-Kha Tran; Jacob Hogue; Miquella Chavez; Mary Fete; Wenli Yu; Tarek Hussein; Ramsey Johnson; Kenneth Huttner; Andrew H Jheon; Ophir D Klein Journal: Am J Med Genet A Date: 2013-05-17 Impact factor: 2.802
Authors: Rolanda A Maxim; Samuel H Zinner; Hisako Matsuo; Theresa M Prosser; Mary Fete; Terry L Leet; Timothy J Fete Journal: ScientificWorldJournal Date: 2012-03-12