Literature DB >> 20681699

Noncovalent encapsulation stabilities in supramolecular nanoassemblies.

Siriporn Jiwpanich1, Ja-Hyoung Ryu, Sean Bickerton, S Thayumanavan.   

Abstract

Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies in aqueous solutions, have implications in evaluating the stability of drug delivery vehicles. This is because exchange dynamics is related to the propensity of a nanocarrier to be leaky. We describe a fluorescence resonance energy transfer (FRET) based method to evaluate guest exchange dynamics in the aqueous phase. We have utilized this method to analyze the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.

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Year:  2010        PMID： 20681699      PMCID： PMC2923926          DOI： 10.1021/ja105059g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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