Alejandro Higuera-Matas1,2, Maria Luisa Soto-Montenegro3,4, Gonzalo L Montoya5,3, Verónica García-Vázquez4, Javier Pascau3, Miguel Miguéns5, Nuria Del Olmo6, Juan José Vaquero3, Carmen García-Lecumberri5, Manuel Desco3,4, Emilio Ambrosio5. 1. Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain. ahigueras@bec.uned.es. 2. Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain. ahigueras@bec.uned.es. 3. Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 4. CIBERSAM, Madrid, Spain. 5. Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain. 6. Department of Pharmaceutical and Food Sciences, School of Pharmacy, CEU University, Madrid, Spain.
Abstract
PURPOSE: To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence. PROCEDURES: The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[¹⁸F]fluoro-D-: glucose (FDG) uptake were studied by positron emission tomography. RESULTS: The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females than in VH-females, although septal metabolism was lower in CP-females after cocaine, reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in males although cocaine reduced the FDG uptake in the dorsal striatum of males that received the VH but not CP. CONCLUSIONS: These results suggest that cannabinoids during periadolescence modify baseline and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females, the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of cocaine should be further investigated.
PURPOSE: To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence. PROCEDURES: The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[¹⁸F]fluoro-D-: glucose (FDG) uptake were studied by positron emission tomography. RESULTS: The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females than in VH-females, although septal metabolism was lower in CP-females after cocaine, reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in males although cocaine reduced the FDG uptake in the dorsal striatum of males that received the VH but not CP. CONCLUSIONS: These results suggest that cannabinoids during periadolescence modify baseline and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females, the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of cocaine should be further investigated.
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