OBJECTIVES: Recent evidence suggests higher prevalence of autism spectrum disorder (ASD) in NICU graduates. This aim of this study was to identify retrospectively early behaviors found more frequently in NICU infants who went on to develop ASD. METHODS: Twenty-eight NICU graduates who later received a diagnosis of ASD were compared with 2169 other NICU graduates recruited from 1994 to 2005. They differed in gender, gestational age, and birth cohort. These characteristics were used to draw a matched control sample (n=112) to determine which, if any, early behaviors discriminated subsequent ASD diagnosis. Behavioral testing at targeted ages (adjusted for gestation) included the Rapid Neonatal Neurobehavioral Assessment (hospital discharge, 1 month), Arousal-Modulated Attention (hospital discharge, 1 and 4 months), and Bayley Scales of Infant Development (multiple times, 4-25 months). RESULTS: At 1 month, children with ASD but not control children had persistent neurobehavioral abnormalities and higher incidences of asymmetric visual tracking and arm tone deficits. At 4 months, children with ASD had continued visual preference for higher amounts of stimulation than did control children, behaving more like newborns. Unlike control children, children with ASD had declining mental and motor performance by 7 to 10 months, resembling infants with severe central nervous system involvement. CONCLUSIONS: Differences in specific behavior domains between NICU graduates who later receive a diagnosis of ASD and matched NICU control children may be identified in early infancy. Studies with this cohort may provide insights to help understand and detect early disabilities, including ASD.
OBJECTIVES: Recent evidence suggests higher prevalence of autism spectrum disorder (ASD) in NICU graduates. This aim of this study was to identify retrospectively early behaviors found more frequently in NICU infants who went on to develop ASD. METHODS: Twenty-eight NICU graduates who later received a diagnosis of ASD were compared with 2169 other NICU graduates recruited from 1994 to 2005. They differed in gender, gestational age, and birth cohort. These characteristics were used to draw a matched control sample (n=112) to determine which, if any, early behaviors discriminated subsequent ASD diagnosis. Behavioral testing at targeted ages (adjusted for gestation) included the Rapid Neonatal Neurobehavioral Assessment (hospital discharge, 1 month), Arousal-Modulated Attention (hospital discharge, 1 and 4 months), and Bayley Scales of Infant Development (multiple times, 4-25 months). RESULTS: At 1 month, children with ASD but not control children had persistent neurobehavioral abnormalities and higher incidences of asymmetric visual tracking and arm tone deficits. At 4 months, children with ASD had continued visual preference for higher amounts of stimulation than did control children, behaving more like newborns. Unlike control children, children with ASD had declining mental and motor performance by 7 to 10 months, resembling infants with severe central nervous system involvement. CONCLUSIONS: Differences in specific behavior domains between NICU graduates who later receive a diagnosis of ASD and matched NICU control children may be identified in early infancy. Studies with this cohort may provide insights to help understand and detect early disabilities, including ASD.
Authors: Susan L Connors; Dorothy E Crowell; Charles G Eberhart; Joshua Copeland; Craig J Newschaffer; Sarah J Spence; Andrew W Zimmerman Journal: J Child Neurol Date: 2005-11 Impact factor: 1.987
Authors: Catherine Limperopoulos; Haim Bassan; Kimberlee Gauvreau; Richard L Robertson; Nancy R Sullivan; Carol B Benson; Lauren Avery; Jane Stewart; Janet S Soul; Steven A Ringer; Joseph J Volpe; Adré J duPlessis Journal: Pediatrics Date: 2007-09 Impact factor: 7.124
Authors: Katja M Lampi; Liisa Lehtonen; Phuong Lien Tran; Auli Suominen; Venla Lehti; P Nina Banerjee; Mika Gissler; Alan S Brown; Andre Sourander Journal: J Pediatr Date: 2012-06-05 Impact factor: 4.406
Authors: Adriana Di Martino; Damien A Fair; Clare Kelly; Theodore D Satterthwaite; F Xavier Castellanos; Moriah E Thomason; R Cameron Craddock; Beatriz Luna; Bennett L Leventhal; Xi-Nian Zuo; Michael P Milham Journal: Neuron Date: 2014-09-17 Impact factor: 17.173
Authors: Ira L Cohen; Judith M Gardner; Bernard Z Karmel; Ha T T Phan; Phyllis Kittler; Tina Rovito Gomez; Maripaz G Gonzalez; Elizabeth M Lennon; Santosh Parab; Anthony Barone Journal: Autism Res Date: 2012-11-16 Impact factor: 5.216
Authors: Tammy Z Movsas; Jennifer A Pinto-Martin; Agnes H Whitaker; Judith F Feldman; John M Lorenz; Steven J Korzeniewski; Susan E Levy; Nigel Paneth Journal: J Pediatr Date: 2013-02-11 Impact factor: 4.406
Authors: Elise Turk; Marion I van den Heuvel; Manon J Benders; Roel de Heus; Arie Franx; Janessa H Manning; Jasmine L Hect; Edgar Hernandez-Andrade; Sonia S Hassan; Roberto Romero; René S Kahn; Moriah E Thomason; Martijn P van den Heuvel Journal: J Neurosci Date: 2019-11-04 Impact factor: 6.167
Authors: Roberta G Pineda; Lauren C Reynolds; Kristin Seefeldt; Claudia L Hilton; Cynthia L Rogers; Terrie E Inder Journal: Am J Occup Ther Date: 2016 Jan-Feb