AIMS: To appraise the ocular manifestations of Puumala hantavirus evoked haemorrhagic fever with renal syndrome nephropathia epidemica (NE) and to clarify the mechanisms of ocular changes in the largest series of patients examined to date. METHODS: 92 eyes of 46 patients with serologically proven NE were examined during the acute phase and after clinical recovery. Ocular symptoms were recorded, and visual acuity, refraction, intraocular pressure and ocular dimensions were evaluated. RESULTS: 88% of the patients experienced decreased intraocular pressure (IOP) (p<0.001), 87% reduced visual acuity, 87% conjunctival chemosis, 82% thickening of the lens (p<0.05), 78% myopic shift (p<0.001), 64% shallowing of the anterior chamber (p<0.05) and 52% shallowing of vitreous length (p<0.05) during the acute phase compared with that measured after clinical recovery. In all, 70% of the patients reported ocular symptoms. CONCLUSION: Ocular symptoms and disturbances are common in acute NE, and the symmetry of the ocular changes reflects the systemic nature of the disease. A decrease in IOP and myopic shift mainly due to thickening of the lens are evident in acute disease. The myopic shift only partially explains the visual disturbances supporting the possible multifactorial origin of the ocular findings in patients with NE.
AIMS: To appraise the ocular manifestations of Puumala hantavirus evoked haemorrhagic fever with renal syndrome nephropathia epidemica (NE) and to clarify the mechanisms of ocular changes in the largest series of patients examined to date. METHODS: 92 eyes of 46 patients with serologically proven NE were examined during the acute phase and after clinical recovery. Ocular symptoms were recorded, and visual acuity, refraction, intraocular pressure and ocular dimensions were evaluated. RESULTS: 88% of the patients experienced decreased intraocular pressure (IOP) (p<0.001), 87% reduced visual acuity, 87% conjunctival chemosis, 82% thickening of the lens (p<0.05), 78% myopic shift (p<0.001), 64% shallowing of the anterior chamber (p<0.05) and 52% shallowing of vitreous length (p<0.05) during the acute phase compared with that measured after clinical recovery. In all, 70% of the patients reported ocular symptoms. CONCLUSION: Ocular symptoms and disturbances are common in acute NE, and the symmetry of the ocular changes reflects the systemic nature of the disease. A decrease in IOP and myopic shift mainly due to thickening of the lens are evident in acute disease. The myopic shift only partially explains the visual disturbances supporting the possible multifactorial origin of the ocular findings in patients with NE.
Authors: Timo Hautala; Nina Hautala; Saara-Mari Mähönen; Tarja Sironen; Eija Pääkkö; Ari Karttunen; Pasi I Salmela; Olli Vainio; Seppo Rytky; Alexander Plyusnin; Antti Vaheri; Olli Vapalahti; Heikki Kauma Journal: BMC Infect Dis Date: 2011-08-14 Impact factor: 3.090
Authors: Joerg Latus; Matthias Schwab; Evelina Tacconelli; Friedrich-Michael Pieper; Daniel Wegener; Juergen Dippon; Simon Müller; David Zakim; Stephan Segerer; Daniel Kitterer; Martin Priwitzer; Barbara Mezger; Birgit Walter-Frank; Angela Corea; Albrecht Wiedenmann; Stefan Brockmann; Christoph Pöhlmann; M Dominik Alscher; Niko Braun Journal: Emerg Infect Dis Date: 2015-01 Impact factor: 6.883
Authors: Emil Pal; Miša Korva; Katarina Resman Rus; Nataša Kejžar; Petra Bogovič; Anica Kurent; Tatjana Avšič-Županc; Franc Strle Journal: PLoS One Date: 2018-05-23 Impact factor: 3.240
Authors: Timo Hautala; Terhi Partanen; Tarja Sironen; Saara-Mari Rajaniemi; Nina Hautala; Olli Vainio; Olli Vapalahti; Heikki Kauma; Antti Vaheri Journal: Clin Dev Immunol Date: 2013-07-31