Literature DB >> 20678526

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression.

C Winter1, B Vollmayr, A Djodari-Irani, J Klein, A Sartorius.   

Abstract

Identifying new treatment approaches for treatment resistant depression (TRD) is an important topic for translational psychiatry. Functional inhibition of the lateral habenula (LHb) has recently been claimed to offer such an option for TRD. Rats which are bred for high susceptibility to develop learned helplessness provide a genetic model for TRD. We used the gamma-aminobutyric acid agonist muscimol to inhibit the LHb in Sprague-Dawley rats with congenital learned helplessness (cLH). Stereotactic pharmacological inhibition of the LHb exerted antidepressive effects in treatment resistant cLH rats.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20678526     DOI： 10.1016/j.bbr.2010.07.034

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  54 in total

Review 1.  Preclinical studies modeling deep brain stimulation for depression.

Authors:  Clement Hamani; José N Nobrega
Journal:  Biol Psychiatry       Date:  2012-06-29       Impact factor: 13.382

2.  A glass full of optimism: enrichment effects on cognitive bias in a rat model of depression.

Authors:  Sophie Helene Richter; Anita Schick; Carolin Hoyer; Katja Lankisch; Peter Gass; Barbara Vollmayr
Journal:  Cogn Affect Behav Neurosci       Date:  2012-09       Impact factor: 3.282

3.  Interactions between the lateral habenula and the hippocampus: implication for spatial memory processes.

Authors:  Romain Goutagny; Michael Loureiro; Jesse Jackson; Joseph Chaumont; Sylvain Williams; Philippe Isope; Christian Kelche; Jean-Christophe Cassel; Lucas Lecourtier
Journal:  Neuropsychopharmacology       Date:  2013-06-05       Impact factor: 7.853

4.  Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal.

Authors:  John A Dani; Mariella De Biasi
Journal:  Cold Spring Harb Perspect Med       Date:  2013-06-01       Impact factor: 6.915

5.  The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.

Authors:  Anthony L Berger; Angela M Henricks; Janelle M Lugo; Hayden R Wright; Collin R Warrick; Martin A Sticht; Maria Morena; Itziar Bonilla; Sarah A Laredo; Rebecca M Craft; Loren H Parsons; Pedro R Grandes; Cecilia J Hillard; Matthew N Hill; Ryan J McLaughlin
Journal:  Biol Psychiatry       Date:  2018-05-08       Impact factor: 13.382

6.  Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels.

Authors:  Wanhong Zuo; Yong Zhang; Guiqin Xie; Danielle Gregor; Alex Bekker; Jiang-Hong Ye
Journal:  Neuropharmacology       Date:  2015-10-22       Impact factor: 5.250

Review 7.  Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.

Authors:  Ruthie E Wittenberg; Shannon L Wolfman; Mariella De Biasi; John A Dani
Journal:  Neuropharmacology       Date:  2020-07-29       Impact factor: 5.250

Review 8.  Translating the Habenula-From Rodents to Humans.

Authors:  Laura-Joy Boulos; Emmanuel Darcq; Brigitte Lina Kieffer
Journal:  Biol Psychiatry       Date:  2016-06-07       Impact factor: 13.382

9.  Efferent pathways of the mouse lateral habenula.

Authors:  Lely A Quina; Lynne Tempest; Lydia Ng; Julie A Harris; Susan Ferguson; Thomas C Jhou; Eric E Turner
Journal:  J Comp Neurol       Date:  2014-08-30       Impact factor: 3.215

Review 10.  Treatment-resistant depression: are animal models of depression fit for purpose?

Authors:  Paul Willner; Catherine Belzung
Journal:  Psychopharmacology (Berl)       Date:  2015-08-21       Impact factor: 4.530
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