AIM: To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI). METHODS: Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies. RESULTS: Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during follow-up showed a lack of expression of cyclin E, which could be a marker of poor prognosis. beta-catenin expression was normal in a high percentage of tumors. CONCLUSION: Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor.
AIM: To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI). METHODS: Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies. RESULTS: Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during follow-up showed a lack of expression of cyclin E, which could be a marker of poor prognosis. beta-catenin expression was normal in a high percentage of tumors. CONCLUSION: Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor.
Authors: W S Samowitz; K Curtin; H H Lin; M A Robertson; D Schaffer; M Nichols; K Gruenthal; M F Leppert; M L Slattery Journal: Gastroenterology Date: 2001-10 Impact factor: 22.682
Authors: R Gryfe; H Kim; E T Hsieh; M D Aronson; E J Holowaty; S B Bull; M Redston; S Gallinger Journal: N Engl J Med Date: 2000-01-13 Impact factor: 91.245
Authors: T Hinoi; M Tani; P C Lucas; K Caca; R L Dunn; E Macri; M Loda; H D Appelman; K R Cho; E R Fearon Journal: Am J Pathol Date: 2001-12 Impact factor: 4.307
Authors: T L Chan; L C Curtis; S Y Leung; S M Farrington; J W Ho; A S Chan; P W Lam; C W Tse; M G Dunlop; A H Wyllie; S T Yuen Journal: Oncogene Date: 2001-08-09 Impact factor: 9.867
Authors: C Müller-Tidow; R Metzger; K Kügler; S Diederichs; G Idos; M Thomas; B Dockhorn-Dworniczak; P M Schneider; H P Koeffler; W E Berdel; H Serve Journal: Cancer Res Date: 2001-01-15 Impact factor: 12.701
Authors: A Loukola; K Eklin; P Laiho; R Salovaara; P Kristo; H Järvinen; J P Mecklin; V Launonen; L A Aaltonen Journal: Cancer Res Date: 2001-06-01 Impact factor: 12.701
Authors: Kristin Wallace; Elizabeth G Hill; David N Lewin; Grace Williamson; Stephanie Oppenheimer; Marvella E Ford; Michael J Wargovich; Franklin G Berger; Susan W Bolick; Melanie B Thomas; Anthony J Alberg Journal: Cancer Causes Control Date: 2013-01-08 Impact factor: 2.506
Authors: Irene Osorio Silla; Daniel Rueda; Yolanda Rodríguez; Juan Luis García; Felipe de la Cruz Vigo; José Perea Journal: World J Gastroenterol Date: 2014-12-14 Impact factor: 5.742
Authors: Kristin Wallace; Carol A Burke; Dennis J Ahnen; Elizabeth L Barry; Robert S Bresalier; Fred Saibil; John A Baron Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-12-09 Impact factor: 4.254
Authors: José Perea; Juana M Cano; Daniel Rueda; Juan L García; Lucía Inglada; Irene Osorio; María Arriba; Jessica Pérez; Miriam Gaspar; Tamara Fernández-Miguel; Yolanda Rodríguez; Javier Benítez; Rogelio González-Sarmiento; Miguel Urioste Journal: Am J Cancer Res Date: 2015-06-15 Impact factor: 6.166