BACKGROUND: The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3-8% of CRC patients, and the prognosis for patients is very poor. We assessed the clinicopathological characteristics of CRC patients with ovarian metastasis and the significance of the resection of ovarian metastases. METHODS: We retrospectively analyzed 22 CRC patients with ovarian metastases. Synchronous ovarian metastases occurred in 8 patients and metachronous ovarian metastases occurred in 14 patients. Peritoneal dissemination was observed in nine patients. RESULTS: The mean follow-up period was 45.3 months. The overall survival at 3 years following diagnosis of ovarian metastases is estimated to be 51.1% and 43.8% at 5 years. The overall survival at 5 years in the group of patients without peritoneal disseminations was 77.9%, which is significantly longer than that of the patients with disseminations (0%) (P = 0.0009). An R0 resection of metastatic sites was achieved in 15 patients and was associated with a significant increase in survival time (P = 0.0002). CONCLUSIONS: Our study shows that aggressive resection of ovarian metastases from CRCs is associated with better overall survival. Peritoneal dissemination is an adverse prognostic factor, but R0 resection significantly improves the overall survival of these patients.
BACKGROUND: The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3-8% of CRCpatients, and the prognosis for patients is very poor. We assessed the clinicopathological characteristics of CRCpatients with ovarian metastasis and the significance of the resection of ovarian metastases. METHODS: We retrospectively analyzed 22 CRCpatients with ovarian metastases. Synchronous ovarian metastases occurred in 8 patients and metachronous ovarian metastases occurred in 14 patients. Peritoneal dissemination was observed in nine patients. RESULTS: The mean follow-up period was 45.3 months. The overall survival at 3 years following diagnosis of ovarian metastases is estimated to be 51.1% and 43.8% at 5 years. The overall survival at 5 years in the group of patients without peritoneal disseminations was 77.9%, which is significantly longer than that of the patients with disseminations (0%) (P = 0.0009). An R0 resection of metastatic sites was achieved in 15 patients and was associated with a significant increase in survival time (P = 0.0002). CONCLUSIONS: Our study shows that aggressive resection of ovarian metastases from CRCs is associated with better overall survival. Peritoneal dissemination is an adverse prognostic factor, but R0 resection significantly improves the overall survival of these patients.
Authors: Karuna Ganesh; Ronak H Shah; Efsevia Vakiani; Garrett M Nash; Hugh P Skottowe; Rona Yaeger; Andrea Cercek; Anne Lincoln; Christina Tran; Neil H Segal; Diane L Reidy; Anna Varghese; Andrew S Epstein; Yukio Sonoda; Dennis Chi; Jose Guillem; Larissa Temple; Philip Paty; Jaclyn Hechtman; Jinru Shia; Martin Weiser; Julio Garcia Aguilar; Nancy Kemeny; Michael F Berger; Leonard Saltz; Zsofia K Stadler Journal: Cancer Date: 2016-11-22 Impact factor: 6.860
Authors: Carling Ursem; Margaret Zhou; Alan Paciorek; Chloe E Atreya; Andrew H Ko; Alan Venook; Li Zhang; Katherine Van Loon Journal: Oncologist Date: 2020-02-07
Authors: R van der Meer; C Bakkers; J A Wegdam; T Lettinga; E G Boerma; F Aarts; I H J T de Hingh; R M H Roumen Journal: Int J Colorectal Dis Date: 2022-07-20 Impact factor: 2.796