R van der Meer1, C Bakkers2, J A Wegdam3, T Lettinga4, E G Boerma5, F Aarts6, I H J T de Hingh2,7, R M H Roumen8,7. 1. Department of Surgery, Máxima Medical Center, P.O. Box 7777, 5500 MB, Veldhoven, The Netherlands. romic.resurge@mmc.nl. 2. Department of Surgery, Catharina Cancer Institute, Eindhoven, The Netherlands. 3. Department of Surgery, Elkerliek Hospital, Helmond, The Netherlands. 4. Department of Surgery, Sint Jans Gasthuis, Weert, The Netherlands. 5. Department of Surgery, Zuyderland Hospital, Geleen, The Netherlands. 6. Department of Surgery, VieCuri Medical Center, Venlo, The Netherlands. 7. GROW - School for Oncology and Development Biology, Maastricht University, Maastricht, Netherlands. 8. Department of Surgery, Máxima Medical Center, P.O. Box 7777, 5500 MB, Veldhoven, The Netherlands.
Abstract
BACKGROUND AND PURPOSE: Previous studies indicated that approximately 3.4% of female colorectal cancer (CRC) patients are at increased risk of developing ovarian metastases (OM). It has been suggested that young women more frequently develop this form of metastatic disease. METHODS: This study evaluated, in 6 Dutch hospitals, the proportion of young women with CRC who developed OM. RESULTS: In a cohort of 200 young (age ≤ 55) women with CRC, the proportion of patients diagnosed with synchronous or metachronous OM was calculated. This study revealed that 5% (n = 10) of young female CRC patients developed ovarian metastases resulting in a 5-year overall survival rate of approximately 40%. Furthermore, six patients had concurrent peritoneal metastases, five patients had bilateral ovarian metastases, and five patients had synchronous metastases, while the median time of the occurrence of metachronous metastases (n = 5) was 19 months. CONCLUSION: This retrospective multicenter cohort study indicates that 5% of young women with CRC either present with or develop OM. This result appears to be clinically relevant and demonstrates the need for improved surveillance for young women diagnosed with CRC.
BACKGROUND AND PURPOSE: Previous studies indicated that approximately 3.4% of female colorectal cancer (CRC) patients are at increased risk of developing ovarian metastases (OM). It has been suggested that young women more frequently develop this form of metastatic disease. METHODS: This study evaluated, in 6 Dutch hospitals, the proportion of young women with CRC who developed OM. RESULTS: In a cohort of 200 young (age ≤ 55) women with CRC, the proportion of patients diagnosed with synchronous or metachronous OM was calculated. This study revealed that 5% (n = 10) of young female CRC patients developed ovarian metastases resulting in a 5-year overall survival rate of approximately 40%. Furthermore, six patients had concurrent peritoneal metastases, five patients had bilateral ovarian metastases, and five patients had synchronous metastases, while the median time of the occurrence of metachronous metastases (n = 5) was 19 months. CONCLUSION: This retrospective multicenter cohort study indicates that 5% of young women with CRC either present with or develop OM. This result appears to be clinically relevant and demonstrates the need for improved surveillance for young women diagnosed with CRC.
Authors: Rebecca L Siegel; Kimberly D Miller; Ann Goding Sauer; Stacey A Fedewa; Lynn F Butterly; Joseph C Anderson; Andrea Cercek; Robert A Smith; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2020-03-05 Impact factor: 508.702
Authors: C Bakkers; R van der Meer; R M Roumen; R J Lurvink; V E Lemmens; F N van Erning; I H de Hingh Journal: Int J Colorectal Dis Date: 2020-03-10 Impact factor: 2.571
Authors: Fanny Er Vuik; Stella Av Nieuwenburg; Marc Bardou; Iris Lansdorp-Vogelaar; Mário Dinis-Ribeiro; Maria J Bento; Vesna Zadnik; María Pellisé; Laura Esteban; Michal F Kaminski; Stepan Suchanek; Ondřej Ngo; Ondřej Májek; Marcis Leja; Ernst J Kuipers; Manon Cw Spaander Journal: Gut Date: 2019-05-16 Impact factor: 23.059