OBJECTIVE: To evaluate the mortality and long-term morbidity rates of extremely low birth weight (ELBW) infants admitted to neonatal intensive care units (NICUs). STUDY DESIGN: This was a longitudinal cohort study of all admissions born between 1983 and 2003 with birth weight ≤ 800 g at a single tertiary NICU. Trends in survival and neurodevelopmental outcome rates at school entry in four 5-year epochs were analyzed. RESULTS: Of 917 admissions, 552 survived to NICU discharge, with significantly increasing survival rates from 46% in epoch 1 to 71% in epoch 4 (P < .0001). Although the overall impairment rate of 30% did not change, the pattern of impairments did. Cognitive (P = .017) and hearing (P = .014) impairment rates increased. Visual impairment rates decreased (P = .042), with a trend toward decreasing cerebral palsy from 20% to 12% (P = .061). CONCLUSIONS: Improved survival of low birth weight preterm infants has been associated with different types of neurodevelopmental impairments, including increased cognitive impairment rates.
OBJECTIVE: To evaluate the mortality and long-term morbidity rates of extremely low birth weight (ELBW) infants admitted to neonatal intensive care units (NICUs). STUDY DESIGN: This was a longitudinal cohort study of all admissions born between 1983 and 2003 with birth weight ≤ 800 g at a single tertiary NICU. Trends in survival and neurodevelopmental outcome rates at school entry in four 5-year epochs were analyzed. RESULTS: Of 917 admissions, 552 survived to NICU discharge, with significantly increasing survival rates from 46% in epoch 1 to 71% in epoch 4 (P < .0001). Although the overall impairment rate of 30% did not change, the pattern of impairments did. Cognitive (P = .017) and hearing (P = .014) impairment rates increased. Visual impairment rates decreased (P = .042), with a trend toward decreasing cerebral palsy from 20% to 12% (P = .061). CONCLUSIONS: Improved survival of low birth weight preterm infants has been associated with different types of neurodevelopmental impairments, including increased cognitive impairment rates.
Authors: Emily W Y Tam; Vann Chau; Donna M Ferriero; A James Barkovich; Kenneth J Poskitt; Colin Studholme; Eric D-Y Fok; Ruth E Grunau; David V Glidden; Steven P Miller Journal: Sci Transl Med Date: 2011-10-19 Impact factor: 17.956
Authors: Jillian Vinall; Steven P Miller; Bruce H Bjornson; Kevin P V Fitzpatrick; Kenneth J Poskitt; Rollin Brant; Anne R Synnes; Ivan L Cepeda; Ruth E Grunau Journal: Pediatrics Date: 2014-02-17 Impact factor: 7.124