OBJECTIVE: To present an estimation of the pregnancy rate after IVF or intracytoplasmic sperm injection stratified by blastocyst morphology and age. DESIGN: Retrospective analysis. SETTING: Private IVF clinic. PATIENT(S): A total of 1,488 single frozen-thawed blastocyst transfer cycles. INTERVENTION(S): All frozen-thawed blastocysts used in the study were obtained in the patients' first oocytes retrieval cycles. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR), viable pregnancy rate (VPR), and delivery rate (DR) according to blastocyst morphological score (Gardner and Schoolcraft score) in three different age groups: women aged 22-33 years, 34-37 years, and 38-45 years. RESULT(S): The quality of blastocysts degraded as age group increased. The proportions of good-quality blastocysts (grades 4 and above) were 62.3%, 56.3%, and 41.1% in age groups of 22-33 years, 34-37 years, and 38-45 years. Within the same blastocyst quality, CPR, VPR, and DR tended to be lower with increased age. Chances of pregnancy were reduced by 60% or more for women 38 years and older with blastocyst morphology of grades 1 and 2. Significant trends were observed for both age and blastocyst morphology groups. CONCLUSION(S): There was a significant correlation between blastocyst quality and CPR, VPR, and DR in addition to the influence of age on the three rates. The findings may help predict successful pregnancy in single-blastocyst transfer.
OBJECTIVE: To present an estimation of the pregnancy rate after IVF or intracytoplasmic sperm injection stratified by blastocyst morphology and age. DESIGN: Retrospective analysis. SETTING: Private IVF clinic. PATIENT(S): A total of 1,488 single frozen-thawed blastocyst transfer cycles. INTERVENTION(S): All frozen-thawed blastocysts used in the study were obtained in the patients' first oocytes retrieval cycles. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR), viable pregnancy rate (VPR), and delivery rate (DR) according to blastocyst morphological score (Gardner and Schoolcraft score) in three different age groups: women aged 22-33 years, 34-37 years, and 38-45 years. RESULT(S): The quality of blastocysts degraded as age group increased. The proportions of good-quality blastocysts (grades 4 and above) were 62.3%, 56.3%, and 41.1% in age groups of 22-33 years, 34-37 years, and 38-45 years. Within the same blastocyst quality, CPR, VPR, and DR tended to be lower with increased age. Chances of pregnancy were reduced by 60% or more for women 38 years and older with blastocyst morphology of grades 1 and 2. Significant trends were observed for both age and blastocyst morphology groups. CONCLUSION(S): There was a significant correlation between blastocyst quality and CPR, VPR, and DR in addition to the influence of age on the three rates. The findings may help predict successful pregnancy in single-blastocyst transfer.
Authors: Sang Min Kang; Sang Won Lee; San Hyun Yoon; Joo Cheol Kim; Jin Ho Lim; Seong Goo Lee Journal: J Assist Reprod Genet Date: 2013-05-30 Impact factor: 3.412